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PAX8 Transcription Factor
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D000072636 |
[A paired box transcription factor that functions in the development of THYROCYTES and the control of thyroid-specific gene expression. Mutations in the PAX8 gene are associated with THYROID DYSGENESIS and THYROID NEOPLASMS.
] |
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PAX9 Transcription Factor
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D051764 |
[A paired box transcription factor that is involved in ODONTOGENESIS.
] |
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PC-3 Cells
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D000078722 |
[An epithelial cell line initiated from a human bone metastasis of a grade IV prostatic ADENOCARCINOMA.
] |
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PC12 Cells
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D016716 |
[A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA. PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR, making the line a useful model system for NERVE CELL differentiation.
] |
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PDZ Domains
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D054731 |
[Protein interaction domains of about 70-90 amino acid residues, named after a common structure found in PSD-95, Discs Large, and Zona Occludens 1 proteins. PDZ domains are involved in the recruitment and interaction of proteins, and aid the formation of protein scaffolds and signaling networks. This is achieved by sequence-specific binding between a PDZ domain in one protein and a PDZ motif in another protein.
] |
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PHD Zinc Fingers
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D000075925 |
[Zinc finger domains of approximately 50 to 80 amino acids in length that are characterized by a conserved Cysteine(3)-Histidine-Cysteine(4) amino acid motif which coordinates binding of two zinc ions. They are similar structurally to RING FINGER DOMAINS, with a globular fold topology of two BETA-SHEETS and an ALPHA-HELIX. PHD fingers occur in many proteins that function in chromatin-mediated gene expression and EPIGENETICS such as POLYCOMB-GROUP PROTEINS.
] |
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PHEX Phosphate Regulating Neutral Endopeptidase
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D053402 |
[A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.
] |
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PII Nitrogen Regulatory Proteins
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D051922 |
[A family of signal transducing adaptor proteins that control the METABOLISM of NITROGEN. They are primarily found in prokaryotes.
] |
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POEMS Syndrome
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D016878 |
[A multisystemic disorder characterized by a sensorimotor polyneuropathy (POLYNEUROPATHIES), organomegaly, endocrinopathy, monoclonal gammopathy, and pigmentary skin changes. Other clinical features which may be present include EDEMA; CACHEXIA; microangiopathic glomerulopathy; pulmonary hypertension (HYPERTENSION, PULMONARY); cutaneous necrosis; THROMBOCYTOSIS; and POLYCYTHEMIA. This disorder is frequently associated with osteosclerotic myeloma. (From Adams et al., Principles of Neurology, 6th ed, p1335; Rev Med Interne 1997;18(7):553-62)
] |
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POU Domain Factors
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D050809 |
[A family of transcription factors characterized by the presence of a bipartite DNA-binding domain known as the POU domain. The POU domain contains two subdomains, a POU-specific domain and a POU-homeodomain. The POU domain was originally identified as a region of approximately 150 amino acids shared between the Pit-1, Oct-1, Oct-2, and Unc-86 transcription factors.
] |
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PPAR alpha
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D047493 |
[A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
] |
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PPAR delta
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D047494 |
[A nuclear transcription factor. It is activated by PROSTACYCLIN.
] |
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PPAR gamma
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D047495 |
[A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.
] |
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PPAR-beta
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D048068 |
[One of the PPAR nuclear transcription factors.
] |
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PQQ Cofactor
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D045542 |
[A pyrrolo-quinoline having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups. It is a coenzyme of some DEHYDROGENASES.
] |
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PR-SET Domains
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D000074463 |
[Highly conserved protein domains of approximately 130 to 140 amino acids. The SET domain was first identified in the Drosophila proteins (S)u(var)3-9, (E)nhancer-of-zeste and (T)rithorax and occurs in other proteins with a variety of functions, including histone-lysine N-methyltransferases. Structurally, it consists of BETA-SHEETS interspersed among loops and turns that result in an "L" shape. The most conserved motifs are a stretch at the C-terminal that contains a strictly conserved tyrosine residue and an adjacent loop that the C-terminal segment passes through to form a "knot". These motifs and especially the tyrosine residue are essential for S-ADENOSYLMETHIONINE binding and catalysis. The PR domain has high homology to the catalytic region of the SET domain and occurs at the N-terminal of PRDM proteins such as PRDM1 PROTEIN.
] |
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PTB-Associated Splicing Factor
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D000072670 |
[An RNA splicing factor that also binds DNA. It is essential for pre-mRNA spicing in the formation of early SPLICEOSOMES and catalytic step II. It binds specifically to polypyrimidine tracts in INTRONS and is involved in the regulation of ALTERNATIVE SPLICING by SIGNAL TRANSDUCTION PATHWAYS.
] |
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PTEN Phosphohydrolase
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D051059 |
[A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.
] |
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PUVA Therapy
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D011701 |
[Photochemotherapy using PSORALENS as the photosensitizing agent and ultraviolet light type A (UVA).
] |
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Pacemaker, Artificial
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D010138 |
[A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).
] |
