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Clinical Observation Units
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D000076542 |
[A hospital unit that serves as a dedicated observation area for emergency room patients when a decision to admit or not is unclear. Also known as clinical decision units or short-stay observation units.
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Clinical Pharmacy Information Systems
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D016303 |
[Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of clinical pharmacy services.
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Clinical Protocols
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D002985 |
[Precise and detailed plans for the study of a medical or biomedical problem and/or plans for a regimen of therapy.
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Clinical Reasoning
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D000086723 |
[Process by which clinicians collect signs and process information to understand the patient's medical situation or problem, and then plan and implement appropriate medical interventions.
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Clinical Studies as Topic
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D000068456 |
[Works about research studies that evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies.
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Clinical Study
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D000068397 |
[A work that reports on the results of a research study to evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. While most clinical studies concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans.
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Clinical Trial
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D016430 |
[A work that reports on the results of a clinical study in which participants are assigned to receive one or more interventions so that researchers can evaluate the interventions on biomedical or health-related outcomes. The assignments are determined by the study protocol. Participants may receive diagnostic, therapeutic, or other types of interventions. For clinical trials on veterinary animals see CLINICAL TRIAL, VETERINARY. Clinical Trials was used for both humans and non-humans prior to 2019.
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Clinical Trial Protocol
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D000078325 |
[The written description of a clinical study. It contains the study's objectives, design, and methods including subject target and/or enrollment criteria. It may also present relevant scientific background and statistical information.
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Clinical Trial Protocols as Topic
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D000078985 |
[Works about the written descriptions of a clinical study. It contains the study's objectives, design, and methods including subject target and/or enrollment criteria. It may also present relevant scientific background and statistical information.
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Clinical Trial, Phase I
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D017426 |
[Work that is the report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques based on a small number of healthy persons and conducted over the period of about a year in either the United States or a foreign country.
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Clinical Trial, Phase II
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D017427 |
[Work that is a report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques based on several hundred volunteers, including a limited number of patients, and conducted over a period of about two years in either the United States or a foreign country.
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Clinical Trial, Phase III
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D017428 |
[Work that is a report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques after phase II trials. A large enough group of patients is studied and closely monitored by physicians for adverse response to long-term exposure, over a period of about three years in either the United States or a foreign country.
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Clinical Trial, Phase IV
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D017429 |
[Work that is a report of a planned post-marketing study of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques that have been approved for general sale after clinical trials, phases I, II, and III. These studies, conducted in the United States or a foreign country, often garner additional data about the safety and efficacy of a product.
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Clinical Trial, Veterinary
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D000077522 |
[A work that is a veterinary clinical study in which animal participants are assigned to receive one or more interventions so that researchers can evaluate the interventions on biomedical or health-related outcomes. The assignments are determined by the study protocol. Animal participants may receive diagnostic, therapeutic, or other types of interventions.
] |
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Clinical Trials Data Monitoring Committees
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D026661 |
[Committees established to review interim data and efficacy outcomes in clinical trials. The findings of these committees are used in deciding whether a trial should be continued as designed, changed, or terminated. Government regulations regarding federally-funded research involving human subjects (the "Common Rule") require (45 CFR 46.111) that research ethics committees reviewing large-scale clinical trials monitor the data collected using a mechanism such as a data monitoring committee. FDA regulations (21 CFR 50.24) require that such committees be established to monitor studies conducted in emergency settings.
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Clinical Trials as Topic
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D002986 |
[Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
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Clinical Trials, Phase I as Topic
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D017321 |
[Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.
, Use of doses at only 1% of the pharmacological dose in humans in order to evaluate the pharmacokinetics. Such trials are sometimes referred to as phase zero trials.
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Clinical Trials, Phase II as Topic
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D017322 |
[Works about studies that are usually controlled to assess the effectiveness and dosage (if appropriate) of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques. These studies are performed on several hundred volunteers, including a limited number of patients with the target disease or disorder, and last about two years. This concept includes phase II studies conducted in both the U.S. and in other countries.
] |
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Clinical Trials, Phase III as Topic
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D017326 |
[Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.
] |
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Clinical Trials, Phase IV as Topic
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D017327 |
[Works about planned post-marketing studies of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques that have been approved for general sale. These studies are often conducted to obtain additional data about the safety and efficacy of a product. This concept includes phase IV studies conducted in both the U.S. and in other countries.
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