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Receptor, Endothelin B
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D044023 |
[A subtype of endothelin receptor found predominantly in the KIDNEY. It may play a role in reducing systemic ENDOTHELIN levels.
] |
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Receptor, EphA1
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D036082 |
[The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. Overproduction of the EphA1 receptor is associated with tumors and tumor cells of epithelial origin. It is also expressed at high levels in LIVER; LUNG; and KIDNEY; which is in contrast to many other members of the Eph receptor that are found primarily in tissues of the nervous system.
] |
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Receptor, EphA2
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D036104 |
[An Eph family receptor found abundantly in tissues of epithelial origin. It is expressed in a diverse array of tissues during embryonic development, suggesting that it may play a role in embryogenesis. In adult tissues high levels of the receptor are expressed in the LUNG; SKIN; SMALL INTESTINE and OVARY.
] |
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Receptor, EphA3
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D036121 |
[An eph family receptor that is found primarily in adult BRAIN and variety of tissues in the developing embryo tissues. During embryonic development high levels of EphA3 receptor expression is seen in the nervous system and coincides with neuronal cell migration, suggesting a role for this protein in axonal pathfinding.
] |
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Receptor, EphA4
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D036122 |
[An eph family receptor found in variety of tissues including BRAIN. During embryogenesis, EphA4 receptor exhibits a diverse spatial and temporal patterns of expression suggesting its role in multiple developmental processes.
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Receptor, EphA5
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D036123 |
[An eph family receptor found primarily in differentiated neuronal tissues. Several isoforms of EphA5 receptor occur due to multiple alternative RNA splicing. The protein is prominently expressed in the NEURONS of the LIMBIC SYSTEM during development and throughout adult life, suggesting its role in the plasticity of limbic structure and function.
] |
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Receptor, EphA6
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D036124 |
[An eph family receptor that is found in a variety of neuronal regions of the BRAIN. In contrast to the other proteins in this class, it is expressed at higher levels in adult tissues than in embryonic tissues.
] |
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Receptor, EphA7
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D036141 |
[An eph family receptor found widely expressed in embryo tissues, including the NERVOUS SYSTEM. In the BRAIN high levels of EphA7 expression occurs in the anterior tectum, medulla, RHOMBENCEPHALON, and SUBCOMMISSURAL ORGAN. Several isoforms of the protein occur due to multiple alternative spicing of the EphA7 mRNA.
] |
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Receptor, EphA8
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D036143 |
[An eph family receptor found exclusively in BRAIN. EphA8 receptors may play a role in the AXONAL GUIDANCE of a subset of tectal commissural NEURONS.
] |
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Receptor, EphB1
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D036225 |
[An eph family receptor found primarily in the nervous system. In the embryonic BRAIN EphB1 receptor expression occurs in the mantle layer and increases with the progression of embryogenesis. In adult brain it is found in the several regions including the CEREBELLUM; CEREBRAL CORTEX; and CAUDATE NUCLEUS; and PUTAMEN.
] |
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Receptor, EphB2
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D036183 |
[An eph family receptor found widely expressed in embryonic and adult tissues. High levels of EphB2 receptor are observed in growing AXONS and NERVE FIBERS. Several isoforms of the protein exist due to multiple alternative mRNA splicing.
] |
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Receptor, EphB3
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D036223 |
[An eph family receptor found in a number of tissues including BRAIN; LUNG; KIDNEY; PANCREAS; INTESTINE; and HEART. During embryogenesis EphB3 receptor is expressed at high levels in the brain.
] |
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Receptor, EphB4
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D036224 |
[An eph family receptor found in a variety of adult and embryonic tissues. Unlike the majority of proteins in this class there is little or no expression of EphB4 receptor in the BRAIN. It has been found at high levels in developing mammary glands and in invasive mammary tumors.
] |
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Receptor, EphB5
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D036201 |
[An eph family receptor found at high levels in adult THYMUS and RETINA. In embryonic tissues it is found in many developing organs.
] |
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Receptor, EphB6
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D036261 |
[An eph family receptor found primarily in BRAIN and THYMUS. The EphB6 receptor is unusual in that its tyrosine kinase domain shares little homology with other members of this class. The unusual tyrosine kinase domain of this receptor appears to result in its lack of tyrosine kinase activity.
] |
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Receptor, ErbB-2
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D018719 |
[A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
] |
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Receptor, ErbB-3
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D020893 |
[A cell surface protein-tyrosine kinase receptor that is specific for NEUREGULINS. It has extensive homology to and can heterodimerize with the EGF RECEPTOR and the ERBB-2 RECEPTOR. Overexpression of the erbB-3 receptor is associated with TUMORIGENESIS.
] |
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Receptor, ErbB-4
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D066247 |
[A cell surface protein-tyrosine kinase receptor that has specificity for EPIREGULIN; BETACELLIN; NEUREGULINS; and HEPARIN-BINDING EGF-LIKE GROWTH-FACTOR.
] |
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Receptor, Fibroblast Growth Factor, Type 1
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D051496 |
[A fibroblast growth factor receptor with specificity for FIBROBLAST GROWTH FACTORS; HEPARAN SULFATE PROTEOGLYCAN; and NEURONAL CELL ADHESION MOLECULES. Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. Fibroblast growth factor receptor 1 contains three extracellular IMMUNOGLOBULIN C2-SET DOMAINS and is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM.
] |
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Receptor, Fibroblast Growth Factor, Type 2
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D051497 |
[A fibroblast growth factor receptor which contains three extracellular IMMUNOGLOBULIN I-SET DOMAINS and is expressed as two isoforms. One receptor isoform is expressed in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform is expressed mainly by EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in craniosynostotic syndromes (e.g., APERT SYNDROME; and CROUZON SYNDROME).
, An isoform of fibroblast growth factor receptor 2 found mainly in EPITHELIAL CELLS that is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10.
] |
