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Prolapse
|
D011391 |
[The protrusion of an organ or part of an organ into a natural or artificial orifice.
] |
|
Prolidase Deficiency
|
D056732 |
[Rare autosomal recessive disorder of metabolism due to mutations in the prolidase gene. It is characterized by recurrent lower extremity skin ulcers, recurrent infections, and FACIES, often with INTELLECTUAL DISABILITY.
] |
|
Proliferating Cell Nuclear Antigen
|
D018809 |
[Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
] |
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Proline
|
D011392 |
[A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.
] |
|
Proline Oxidase
|
D011394 |
[The first enzyme of the proline degradative pathway. It catalyzes the oxidation of proline to pyrroline-5-carboxylic acid in the presence of oxygen and water. The action is not reversible. The specific activity of proline oxidase increases with age. EC 1.5.3.-.
] |
|
Proline-Directed Protein Kinases
|
D038461 |
[A subclass of protein serine-threonine kinases that phosphorylate proteins on a SERINE or THREONINE residue that is immediately preceding a PROLINE residue.
] |
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Proline-Rich Protein Domains
|
D055232 |
[Protein domains that are enriched in PROLINE. The cyclical nature of proline causes the peptide bonds it forms to have a limited degree of conformational mobility. Therefore the presence of multiple prolines in close proximity to each other can convey a distinct conformational arrangement to a peptide chain.
] |
|
Prolotherapy
|
D000075527 |
[Treatment of MUSCULOSKELETAL PAIN by injecting a substance into a joint space, ligament, or tendon to promote the growth of new tissue.
] |
|
Prolyl Hydroxylases
|
D064828 |
[Enzymes that specifically hydroxylate PROLINE residues on proteins.
] |
|
Prolyl Oligopeptidases
|
D000085822 |
[A family of serine proteases with specificity for proline-specific cleavage of peptides that are not longer than 30 amino acids. In humans it is broadly distributed in all tissues with higher activity found in the brain.
] |
|
Prolyl-Hydroxylase Inhibitors
|
D064800 |
[Compounds that inhibit the action of HYDROXYLASES that act on PROLINE to form HYDROXYPROLINE.
] |
|
Promazine
|
D011395 |
[A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
] |
|
Promedol
|
D011396 |
[A narcotic analgesic similar to MEPERIDINE; it exists in four stereoisomers, two of which, the beta (isopromedol) and the gamma (trimeperidine) are active.
] |
|
Promegestone
|
D011397 |
[A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.
] |
|
Prometaphase
|
D049468 |
[The phase of cell nucleus division following PROPHASE, when the breakdown of the NUCLEAR ENVELOPE occurs and the MITOTIC SPINDLE APPARATUS enters the nuclear region and attaches to the KINETOCHORES.
] |
|
Promethazine
|
D011398 |
[A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
] |
|
Promethium
|
D011399 |
[A radioactive element of the rare earth family of metals. It has the atomic symbol Pm, and atomic number 61. It has been used in the construction of atomic batteries, in the preparation of self-luminous compounds, and as a beta-particle source for thickness gauges.
] |
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Prometryne
|
D011400 |
[A triazine used as a selective pre- and post-emergence herbicide. (From Merck Index, 11th ed)
] |
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Promoter Regions, Genetic
|
D011401 |
[DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
] |
|
Promyelocytic Leukemia Protein
|
D000071156 |
[A tripartite motif protein that contains three ZINC FINGERS, including a RING FINGER DOMAIN, at its N-terminal. Several nuclear and one cytoplasmic isoforms result from alternative splicing of the PML gene; most nuclear isoforms localize to subnuclear structures (PML nuclear bodies) that are disrupted in ACUTE PROMYELOCYTIC LEUKEMIA cells.
] |
