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Phosphoenolpyruvate Carboxykinase (GTP)
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D010729 |
[An enzyme of the lyase class that catalyzes the conversion of GTP and oxaloacetate to GDP, phosphoenolpyruvate, and carbon dioxide. This reaction is part of gluconeogenesis in the liver. The enzyme occurs in both the mitochondria and cytosol of mammalian liver. (From Dorland, 27th ed) EC 4.1.1.32.
] |
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Phosphoenolpyruvate Carboxylase
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D010730 |
[An enzyme with high affinity for carbon dioxide. It catalyzes irreversibly the formation of oxaloacetate from phosphoenolpyruvate and carbon dioxide. This fixation of carbon dioxide in several bacteria and some plants is the first step in the biosynthesis of glucose. EC 4.1.1.31.
] |
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Phosphoenolpyruvate Sugar Phosphotransferase System
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D010731 |
[The bacterial sugar phosphotransferase system (PTS) that catalyzes the transfer of the phosphoryl group from phosphoenolpyruvate to its sugar substrates (the PTS sugars) concomitant with the translocation of these sugars across the bacterial membrane. The phosphorylation of a given sugar requires four proteins, two general proteins, Enzyme I and HPr and a pair of sugar-specific proteins designated as the Enzyme II complex. The PTS has also been implicated in the induction of synthesis of some catabolic enzyme systems required for the utilization of sugars that are not substrates of the PTS as well as the regulation of the activity of ADENYLYL CYCLASES. EC 2.7.1.-.
] |
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Phosphofructokinase-1
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D010732 |
[An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE; PHOSPHOFRUCTOKINASE-1, LIVER TYPE; and PHOSPHOFRUCTOKINASE-1, TYPE C; found in platelets, brain, and other tissues.
] |
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Phosphofructokinase-1, Liver Type
|
D025501 |
[An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. In human liver, the 6-phosphofructose-1-kinase exists as the homotetramer of L subunits.
] |
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Phosphofructokinase-1, Muscle Type
|
D025203 |
[An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. In humans, PHOSPHOFRUCTOKINASE-1 in muscle exists as the homotetramer of M subunits. Defects in this muscle enzyme cause GLYCOGEN STORAGE DISEASE TYPE VII, also known as Tarui's disease.
] |
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Phosphofructokinase-1, Type C
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D025502 |
[An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. In the humans, 6-phosphofructose-1-kinase isozyme C is found in platelets, brain, heart, kidney, colon and testis. This isozyme C can exist as the homotetramer of C subunits (P subunits), or heterotetramer of C type and L type subunits.
] |
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Phosphofructokinase-2
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D025481 |
[An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.
] |
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Phosphofructokinases
|
D025221 |
[Allosteric enzymes that regulate glycolysis and gluconeogenesis. These enzymes catalyze phosphorylation of fructose-6-phosphate to either fructose-1,6-bisphosphate (PHOSPHOFRUCTOKINASE-1 reaction), or to fructose-2,6-bisphosphate (PHOSPHOFRUCTOKINASE-2 reaction).
] |
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Phosphoglucomutase
|
D010733 |
[An enzyme that catalyzes the conversion of alpha D-glucose 1-phosphate to alpha D-glucose 6-phosphate. EC 5.4.2.2.
] |
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Phosphogluconate Dehydrogenase
|
D010734 |
[An enzyme of the oxidoreductase class that catalyzes the reaction 6-phospho-D-gluconate and NADP+ to yield D-ribulose 5-phosphate, carbon dioxide, and NADPH. The reaction is a step in the pentose phosphate pathway of glucose metabolism. (From Dorland, 27th ed) EC 1.1.1.43.
] |
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Phosphoglycerate Dehydrogenase
|
D050543 |
[An enzyme that catalyzes the oxidation of 3-phosphoglycerate to 3-phosphohydroxypyruvate. It takes part in the L-SERINE biosynthesis pathway.
] |
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Phosphoglycerate Kinase
|
D010735 |
[An enzyme catalyzing the transfer of a phosphate group from 3-phospho-D-glycerate in the presence of ATP to yield 3-phospho-D-glyceroyl phosphate and ADP. EC 2.7.2.3.
] |
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Phosphoglycerate Mutase
|
D010736 |
[An enzyme that catalyzes the conversion of 2-phospho-D-glycerate to 3-phospho-D-glycerate.
] |
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Phosphoinositide Phosphatases
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D000072180 |
[Phosphatases that catalyze the hydrolysis of phosphate groups on PHOSPHATIDYLINOSITOLS.
] |
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Phosphoinositide Phospholipase C
|
D054801 |
[A type C phospholipase with specificity towards PHOSPHATIDYLINOSITOLS that contain INOSITOL 1,4,5-TRISPHOSPHATE. Many of the enzymes listed under this classification are involved in intracellular signaling.
] |
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Phosphoinositide-3 Kinase Inhibitors
|
D000081082 |
[Agents that inhibit PHOSPHOINOSITIDE-3 KINASE activity.
] |
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Phospholipase A2 Inhibitors
|
D064801 |
[Compounds that inhibit or block the activity of a PHOSPHOLIPASE A2 enzyme.
] |
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Phospholipase C beta
|
D054799 |
[A phosphoinositide phospholipase C subtype that is primarily regulated by its association with HETEROTRIMERIC G-PROTEINS. It is structurally related to PHOSPHOLIPASE C DELTA with the addition of C-terminal extension of 400 residues.
] |
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Phospholipase C delta
|
D054803 |
[A phosphoinositide phospholipase C subtype that is structurally defined by the presence of an N-terminal pleckstrin-homology and EF-hand domains, a central catalytic domain, and a C-terminal calcium-dependent membrane-binding domain.
] |
