A musculoskeletal system symptom that is characterized by necrosis (i.e. tissue death) of soft tissue, including muscle, fat, blood vessels, nerves, tendons, and tissues that surround the bones and joints. [ url:https://medlineplus.gov/ency/article/001443.htm url:https://www.health.ny.gov/statistics/cancer/registry/abouts/soft_tissue.htm ]