A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.

Synonyms: 3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase Multifunctional Protein-2, Peroxisomal Peroxisomal Multifunctional Protein-2 4, 17-beta-Hydroxysteroid Dehydrogenase Peroxisomal Multifunctional Protein 2 EC 4.2.1.107 17 beta Hydroxysteroid Dehydrogenase 4 Dehydrogenase 4, 17-beta-Hydroxysteroid Peroxisomal Multifunctional Enzyme Type 2 17-beta-Hydroxysteroid Dehydrogenase 4