A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.

Synonyms: cGMP-Dependent 3',5'-Cyclic Phosphodiesterase Cyclic Nucleotide Phosphodiesterase PDE2 Family PDE2 Phosphodiesterases cGMP Dependent 3',5' Cyclic Phosphodiesterase Cyclic Nucleotide Phosphodiesterases, Type 2 Cyclic Nucleotide Phosphodiesterases, Type 2A Phosphodiesterase 2A PDE2 Phosphodiesterase Phosphodiesterase, Cyclic GMP-Stimulated EC 3.1.4.17 Cyclic GMP-Stimulated Phosphodiesterase 3',5'-Cyclic Phosphodiesterase, cGMP-Dependent Cyclic GMP Stimulated Phosphodiesterase