A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.

An alternatively spliced variant of tyrosine protein phosphatase, non-receptor type 22.

Synonyms: PTPase, Lyp1 Protein Tyrosine Phosphatase, Non-Receptor Type 22 PTPase, Lyp2 PTPN-22 Protein PTPN 22 Protein Protein Tyrosine Phosphatase, Non Receptor Type 22 Tyrosine Protein Phosphatase, Non-Receptor Type 22 Lyp1 PTPase Lyp2 PTPase Protein-Tyrosine Phosphatase Lyp PTPase Lyp Tyrosine Protein Phosphatase, Non Receptor Type 22 EC 3.1.3.48 Lymphoid Phosphatase Protein Tyrosine Phosphatase Lyp