A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.

Synonyms: PEST-Enriched Phosphatase Protein Tyrosine Phosphatase, Non-Receptor Type 12 PEST Enriched Phosphatase PTPase, PEP Protein Tyrosine Phosphatase, Non Receptor Type 12 Phosphatase, PEST-Enriched EC 3.1.3.48 PTP-PEST PEP Protein Tyrosine Phosphatase PEP PTPase