A subtype of non-receptor protein tyrosine phosphatases that includes two distinctive targeting motifs; an N-terminal motif specific for the INSULIN RECEPTOR, and a C-terminal motif specific for the SH3 domain containing proteins. This subtype includes a hydrophobic domain which localizes it to the ENDOPLASMIC RETICULUM.

Synonyms: Protein-Tyrosine Phosphatase HA2 Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatase HA2 PTPase 1B EC 3.1.3.48 Protein Tyrosine Phosphatase 1B Protein Tyrosine Phosphatase, Non Receptor Type 1 PTPase HA2