A subcategory of phospholipases A2 that are secreted from cells. They are 14 kDa proteins containing multiple disulfide-bonds and access their substrate via an interfacial binding site that interacts with phospholipid membranes. In addition specific PHOSPHOLIPASE A2 RECEPTORS can bind to and internalize the enzymes.

Synonyms: EC 3.1.1.4 Phospholipases A2, Secreted A2, Secreted Phospholipase Secretory Phospholipase A2 Phospholipase A2, Secreted Phospholipases A2, Secretory Phospholipase A2, Secretory SPLA2 Phospholipases sPLA(2) Secreted Phospholipase A2 Secreted Phospholipases A2 Secretory Phospholipases A2 Phospholipases, SPLA2 sPLA2 sPLA2s