An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.

Synonyms: (2'-5')An Polymerase 2',5' Oligoadenylate Synthetase 2-5A Synthetase 2',5' Oligoadenylate Polymerase Oligoadenylate Synthetase, 2,5 2,5 Oligoadenylate Synthetase EC 2.7.7.84 2',5'-Oligo(A) Polymerase Synthetase, 2',5'-Oligoadenylate Synthetase, 2,5 Oligoadenylate 2',5'-Oligoadenylate Polymerase 2',5'-Oligo(A) Synthetase ATP-(2'-5')oligo(A)adenylyltransferase Polymerase, 2',5'-Oligoadenylate 2,5 Oligoadenylate Polymerase Polymerase, 2,5 Oligoadenylate Oligoadenylate Polymerase, 2,5 2',5'-Oligoadenylate Synthetase