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Neuronal Calcium-Sensor Proteins
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D051580 |
[A family of intracellular calcium-sensing proteins found predominately in NEURONS and PHOTORECEPTOR CELLS. They contain EF HAND MOTIFS and undergo conformational changes upon calcium-binding. Neuronal calcium-sensor proteins interact with other regulatory proteins to mediate physiological responses to a change in intracellular calcium concentration.
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Neuronal Ceroid-Lipofuscinoses
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D009472 |
[This type is caused by mutation in the gene (CLN1or PPT1) encoding palmitoyl-protein thioesterase (THIOLESTER HYDROLASES), an enzyme involved in catabolism of lipid-modified proteins.
, This type is caused by mutation in the CLN2 gene encoding tripeptidyl-peptidase I, a lysosomal serine protease.
, This type is caused by mutation in the CLN3 gene encoding a lysosomal integral membrane protein (Battenin).
, A group of severe neurodegenerative diseases characterized by intracellular accumulation of autofluorescent wax-like lipid materials (CEROID; LIPOFUSCIN) in neurons. There are several subtypes based on mutations of the various genes, time of disease onset, and severity of the neurological defects such as progressive DEMENTIA; SEIZURES; and visual failure.
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Neuronal Outgrowth
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D000071446 |
[Formation of neuronal processes (AXONS; NEURITES) toward a target cell.
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Neuronal Plasticity
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D009473 |
[The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
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Neuronal Tract-Tracers
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D056325 |
[Substances used to identify the location and to characterize the types of NEURAL PATHWAYS.
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Neuronavigation
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D038361 |
[Intraoperative computer-assisted 3D navigation and guidance system generally used in neurosurgery for tracking surgical tools and localize them with respect to the patient's 3D anatomy. The pre-operative diagnostic scan is used as a reference and is transferred onto the operative field during surgery.
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Neurons
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D009474 |
[The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
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Neurons, Afferent
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D009475 |
[Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.
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Neurons, Efferent
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D009476 |
[Neurons which send impulses peripherally to activate muscles or secretory cells.
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Neuropathology
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D000069338 |
[The branch of medicine and biomedical science concerned with diseases of the nervous system.
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Neuropeptide Y
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D009478 |
[A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones.
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Neuropeptides
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D009479 |
[Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.
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Neuropharmacology
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D009480 |
[The branch of pharmacology dealing especially with the action of drugs upon various parts of the nervous system.
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Neurophysins
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D009481 |
[Carrier proteins for OXYTOCIN and VASOPRESSIN. They are polypeptides of about 10-kDa, synthesized in the HYPOTHALAMUS. Neurophysin I is associated with oxytocin and neurophysin II is associated with vasopressin in their respective precursors and during transportation down the axons to the neurohypophysis (PITUITARY GLAND, POSTERIOR).
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Neurophysiological Monitoring
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D064926 |
[The systematic checking of the condition and function of a patient's CENTRAL NERVOUS SYSTEM during disease periods or following injuries, using various NEUROLOGICAL DIAGNOSTIC TECHNIQUES.
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Neurophysiology
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D009482 |
[The scientific discipline concerned with the physiology of the nervous system.
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Neuropil
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D019581 |
[A dense intricate feltwork of interwoven fine glial processes, fibrils, synaptic terminals, axons, and dendrites interspersed among the nerve cells in the gray matter of the central nervous system.
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Neuropil Threads
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D019600 |
[Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.
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Neuropilin-1
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D039942 |
[A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.
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Neuropilin-2
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D039943 |
[Transmembrane receptor for CLASS 3 SEMAPHORINS and several vascular endothelial growth factor isoforms. Neuropilin-2 functions either as a homodimer or as a heterodimer with NEUROPILIN-1. The binding affinity of neuropilin-2 varies for different class 3 semaphorin isoforms and is dependent on the composition of the dimer. The protein also forms receptor complexes with plexins and with VEGF RECEPTORS, which alters the binding characteristics of the receptor.
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