All individuals in MeSH

Label Id Description
NADPH Oxidase 4 D000074663 [An NADPH oxidase that is strongly expressed in the kidney. It forms a complex with CYBA-P22PHOX and produces intracellular SUPEROXIDES that may regulate cellular signaling in APOPTOSIS; BONE RESORPTION; and NF-KAPPA B activation. ]
NADPH Oxidase 5 D000074664 [An NADPH oxidase that contains four EF HANDS and is expressed primarily by SPERMATOCYTES and LYMPHOCYTES, as well as by endothelial cells. It functions as a calcium-dependent proton channel to generate SUPEROXIDES that regulate cell growth, APOPTOSIS; and PHYSIOLOGIC ANGIOGENESIS. ]
NADPH Oxidases D019255 [A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC. ]
NADPH-Ferrihemoprotein Reductase D009251 [A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. EC 1.6.2.4. ]
NAV1.1 Voltage-Gated Sodium Channel D062550 [A voltage-gated sodium channel subtype that is predominantly expressed in the CENTRAL NERVOUS SYSTEM. Defects in the SCN1A gene which codes for the alpha subunit of this sodium channel are associated with DRAVET SYNDROME, generalized epilepsy with febrile seizures plus, type 2 (GEFS+2), and familial hemiplegic migraine type 3. ]
NAV1.2 Voltage-Gated Sodium Channel D062551 [A voltage-gated sodium channel subtype that mediates the sodium ion permeability of excitable membranes. Defects in the SCN2A gene which codes for the alpha subunit of this sodium channel are associated with benign familial infantile seizures type 3, and early infantile epileptic encephalopathy type 11. ]
NAV1.3 Voltage-Gated Sodium Channel D062552 [A voltage-gated sodium channel subtype found in neuronal tissue that mediates the sodium ion PERMEABILITY of excitable membranes. ]
NAV1.4 Voltage-Gated Sodium Channel D062553 [A voltage-gated sodium channel subtype that mediates the sodium ion PERMEABILITY of SKELETAL MYOCYTES. Defects in the SCN4A gene, which codes for the alpha subunit of this sodium channel, are associated with several MYOTONIC DISORDERS. ]
NAV1.5 Voltage-Gated Sodium Channel D062554 [A voltage-gated sodium channel subtype that mediates the sodium ion PERMEABILITY of CARDIOMYOCYTES. Defects in the SCN5A gene, which codes for the alpha subunit of this sodium channel, are associated with a variety of CARDIAC DISEASES that result from loss of sodium channel function. ]
NAV1.6 Voltage-Gated Sodium Channel D062557 [A voltage-gated sodium channel subtype found widely expressed in neurons of the central and peripheral nervous systems. Defects in the SCN8A gene which codes for the alpha subunit of this sodium channel are associated with ATAXIA and cognitive deficits. ]
NAV1.7 Voltage-Gated Sodium Channel D062556 [A voltage-gated sodium channel subtype found widely expressed in nociceptive primary sensory neurons. Defects in the SCN9A gene, which codes for the alpha subunit of this sodium channel, are associated with several pain sensation-related disorders. ]
NAV1.8 Voltage-Gated Sodium Channel D062559 [A voltage-gated sodium channel subtype that is expressed in nociceptors, including spinal and trigeminal sensory neurons. It plays a role in the transmission of pain signals induced by cold, heat, and mechanical stimuli. ]
NAV1.9 Voltage-Gated Sodium Channel D062558 [A voltage-gated sodium channel subtype found in the neurons of the NERVOUS SYSTEM and DORSAL ROOT GANGLIA. It may play a role in the generation of heat and mechanical pain hypersensitivity. ]
NEDD8 Protein D000075687 [A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins ]
NF-E2 Transcription Factor D050983 [A basic-leucine zipper transcription factor that regulates GLOBIN gene expression and is related to TRANSCRIPTION FACTOR AP-1. NF-E2 consists of a small MAF protein subunit and a tissue-restricted 45 kDa subunit. ]
NF-E2 Transcription Factor, p45 Subunit D050984 [A tissue-specific subunit of NF-E2 transcription factor that interacts with small MAF PROTEINS to regulate gene expression. P45 NF-E2 protein is expressed primarily in MEGAKARYOCYTES; ERYTHROID CELLS; and MAST CELLS. ]
NF-E2-Related Factor 1 D051265 [A basic-leucine zipper transcription factor that is involved in regulating inflammatory responses, MORPHOGENESIS, and HEME biosynthesis. ]
NF-E2-Related Factor 2 D051267 [A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage. ]
NF-KappaB Inhibitor alpha D000072000 [An I-kappa B protein that inhibits the activity of dimeric NF-KAPPA B P50-REL complexes, sequesters transcription factor NF-kappaB as an inactive complex in the cytoplasm; and prevents NF-kappaB nuclear translocation and DNA binding. ]
NF-kappa B D016328 [Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA. ]