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Meta-Analysis
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D017418 |
[Works consisting of studies using a quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc. It is often an overview of clinical trials. It is usually called a meta-analysis by the author or sponsoring body and should be differentiated from reviews of literature.
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Meta-Analysis as Topic
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D015201 |
[A quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in the areas of research and medicine.
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Metabolic Clearance Rate
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D008657 |
[Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.
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Metabolic Detoxication, Phase I
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D050216 |
[Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
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Metabolic Detoxication, Phase II
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D050217 |
[The conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE conjugation; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products.
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Metabolic Diseases
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D008659 |
[Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)
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Metabolic Engineering
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D060847 |
[Methods and techniques used to genetically modify cells' biosynthetic product output and develop conditions for growing the cells as BIOREACTORS.
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Metabolic Equivalent
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D055686 |
[A measurement of OXYGEN uptake in a sitting, resting person (resting oxygen consumption), varying with age, sex, race, and other factors. In normal adult men, one MET is approximately 3.5 ml O2/kg/min of body weight. Oxygen uptake during activities or work can be measured in METs which can be use to determine health status and exercise prescription.
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Metabolic Flux Analysis
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D064688 |
[Measurement of cells' substrate utilization and biosynthetic output for modeling of METABOLIC NETWORKS.
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Metabolic Networks and Pathways
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D053858 |
[Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.
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Metabolic Side Effects of Drugs and Substances
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D065606 |
[Specific effects of drugs and substances on metabolic pathways such as those occurring through the CYTOCHROME P-450 ENZYME SYSTEM. These include effects that often result in DRUG INTERACTIONS; FOOD-DRUG INTERACTIONS; and HERB-DRUG INTERACTIONS.
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Metabolic Syndrome
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D024821 |
[A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components not only include metabolic dysfunctions of METABOLIC SYNDROME but also HYPERTENSION, and ABDOMINAL OBESITY.
, A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.
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Metabolism
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D008660 |
[The chemical reactions in living organisms by which energy is provided for vital processes and activities and new material is assimilated.
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Metabolism, Inborn Errors
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D008661 |
[Errors in metabolic processes resulting from inborn genetic mutations that are inherited or acquired in utero.
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Metabolome
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D055442 |
[A measurement of all the metabolites of a sample of cells or tissue.
, The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.
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Metabolomics
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D055432 |
[The study of metabolite patterns in biological samples and correlation with xenobiotic challenge and disease states. The word was coined by Nicholson in 1999.
, The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.
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Metacarpal Bones
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D050279 |
[The five cylindrical bones of the METACARPUS, articulating with the CARPAL BONES proximally and the PHALANGES OF FINGERS distally.
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Metacarpophalangeal Joint
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D008662 |
[The articulation between a metacarpal bone and a phalanx.
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Metacarpus
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D008663 |
[The region of the HAND between the WRIST and the FINGERS.
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Metacercariae
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D058488 |
[Encysted cercaria which house the intermediate stages of trematode parasites in tissues of an intermediate host.
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