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Interleukin-10 Receptor alpha Subunit
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D053709 |
[A subunit of the interleukin-10 receptor. It plays a role in receptor signaling by associating with JANUS KINASE 1.
] |
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Interleukin-10 Receptor beta Subunit
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D053710 |
[A subunit of the interleukin-10 receptor. It plays a role in receptor signaling by associating with TYK2 KINASE.
] |
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Interleukin-11
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D017370 |
[A lymphohematopoietic cytokine that plays a role in regulating the proliferation of ERYTHROID PRECURSOR CELLS. It induces maturation of MEGAKARYOCYTES which results in increased production of BLOOD PLATELETS. Interleukin-11 was also initially described as an inhibitor of ADIPOGENESIS of cultured preadipocytes.
] |
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Interleukin-11 Receptor alpha Subunit
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D053703 |
[A low affinity interleukin-11 receptor subunit that combines with the CYTOKINE RECEPTOR GP130 to form a high affinity receptor for INTERLEUKIN-11. Multiple isoforms of this protein exist due to ALTERNATIVE SPLICING of its MRNA.
] |
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Interleukin-12
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D018664 |
[A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
] |
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Interleukin-12 Receptor beta 1 Subunit
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D053711 |
[A subunit of the interleukin-12 receptor. It plays a role in receptor signaling by associating with TYK2 KINASE 1.
] |
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Interleukin-12 Receptor beta 2 Subunit
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D053712 |
[A subunit of the interleukin-12 receptor. It plays a role in receptor signaling by associating with JANUS KINASE 2.
] |
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Interleukin-12 Subunit p35
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D053765 |
[A subunit of interleukin-12. It binds to the INTERLEUKIN-12 SUBUNIT P40 via a disulfide bond that results in the active cytokine.
] |
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Interleukin-12 Subunit p40
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D053762 |
[A cytokine subunit that is a component of both interleukin-12 and interleukin-23. It binds to the INTERLEUKIN-12 SUBUNIT P35 via a disulfide bond to form interleukin-12 and to INTERLEUKIN-23 SUBUNIT P19 to form interleukin-23.
] |
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Interleukin-13
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D018793 |
[A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.
] |
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Interleukin-13 Receptor alpha1 Subunit
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D053661 |
[An interleukin receptor subunit with specificity for INTERLEUKIN-13. It dimerizes with the INTERLEUKIN-4 RECEPTOR ALPHA SUBUNIT to form the TYPE II INTERLEUKIN-4 RECEPTOR which has specificity for both INTERLEUKIN-4 and INTERLEUKIN-13. Signaling of this receptor subunit occurs through the interaction of its cytoplasmic domain with JANUS KINASES such as the TYK2 KINASE.
] |
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Interleukin-13 Receptor alpha2 Subunit
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D053663 |
[An interleukin-13 receptor subunit that is closely-related to the INTERLEUKIN-13 RECEPTOR ALPHA1 SUBUNIT. The receptor is found as a monomeric protein and has been considered to be a decoy receptor for interleukin-13 due the fact that it lacks cytoplasmic signaling domains.
] |
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Interleukin-15
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D019409 |
[Cytokine that stimulates the proliferation of T-LYMPHOCYTES and shares biological activities with IL-2. IL-15 also can induce proliferation and differentiation of B-LYMPHOCYTES.
] |
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Interleukin-15 Receptor alpha Subunit
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D053720 |
[A low affinity interleukin-15 receptor subunit that combines with the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN to form a high affinity receptor for INTERLEUKIN-15.
] |
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Interleukin-16
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D019410 |
[A cytokine produced by activated T-LYMPHOCYTES that stimulates the migration of CD4-POSITIVE LYMPHOCYTES and monocytes. It has been reported to suppress HIV replication.
] |
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Interleukin-17
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D020381 |
[A proinflammatory cytokine produced primarily by T-LYMPHOCYTES or their precursors. Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.
] |
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Interleukin-18
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D020382 |
[A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.
] |
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Interleukin-18 Receptor alpha Subunit
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D053727 |
[A subunit of the interleukin-18 receptor that is responsible of extracellular binding of IL-18.
] |
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Interleukin-18 Receptor beta Subunit
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D053728 |
[A subunit of the interleukin-18 receptor that plays a role in receptor signaling by association of its cytoplasmic domain with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88.
] |
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Interleukin-1alpha
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D053582 |
[An interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form. Unlike INTERLEUKIN-1BETA both membrane-bound and secreted forms of interleukin-1alpha are biologically active.
] |