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Insulin Glargine
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D000069036 |
[A recombinant LONG ACTING INSULIN and HYPOGLYCEMIC AGENT that is used to manage BLOOD GLUCOSE in patients with DIABETES MELLITUS.
] |
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Insulin Infusion Systems
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D007332 |
[Portable or implantable devices for infusion of insulin. Includes open-loop systems which may be patient-operated or controlled by a pre-set program and are designed for constant delivery of small quantities of insulin, increased during food ingestion, and closed-loop systems which deliver quantities of insulin automatically based on an electronic glucose sensor.
] |
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Insulin Lispro
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D061268 |
[Insulin that has been modified so that the B-chain contains a LYSINE at position 28 instead of a PROLINE and a PROLINE at position 29 instead of a LYSINE. It is used to manage BLOOD GLUCOSE levels in patients with TYPE 2 DIABETES.
] |
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Insulin Receptor Substrate Proteins
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D055504 |
[A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.
] |
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Insulin Resistance
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D007333 |
[Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
] |
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Insulin Secretion
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D000078790 |
[Production and release of insulin from PANCREATIC BETA CELLS that primarily occurs in response to elevated BLOOD GLUCOSE levels.
] |
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Insulin, Isophane
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D007336 |
[An intermediate-acting INSULIN preparation with onset time of 2 hours and duration of 24 hours. It is produced by crystallizing ZINC-insulin-PROTAMINES at neutral pH 7. Thus it is called neutral protamine Hagedorn for inventor Hans Christian Hagedorn.
] |
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Insulin, Lente
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D061405 |
[An insulin, zinc chloride preparation in the form of a suspension of crystals and amorphous material in a ratio of approximately 7:3. Typically, lente insulin has a duration of activity that lasts between 13-20 hours after dosage.
] |
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Insulin, Long-Acting
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D049528 |
[Insulin formulations that contain substances that retard absorption thus extending the time period of action.
] |
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Insulin, Regular, Human
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D061386 |
[Regular insulin preparations that contain the HUMAN insulin peptide sequence.
] |
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Insulin, Regular, Pork
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D061389 |
[Regular insulin preparations that contain the SUS SCROFA insulin peptide sequence.
] |
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Insulin, Short-Acting
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D061266 |
[Insulin derivatives and preparations that are designed to induce a rapid HYPOGLYCEMIC EFFECT.
] |
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Insulin, Ultralente
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D061406 |
[A preparation of insulin and zinc chloride in the form of a crystalline suspension. Typically the duration of ultralente insulin activity lasts between 18-30 hours after dosage.
] |
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Insulin-Like Growth Factor Binding Protein 1
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D018970 |
[One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)
] |
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Insulin-Like Growth Factor Binding Protein 2
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D018971 |
[One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.
] |
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Insulin-Like Growth Factor Binding Protein 3
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D018972 |
[One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.
] |
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Insulin-Like Growth Factor Binding Protein 4
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D018974 |
[One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.
] |
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Insulin-Like Growth Factor Binding Protein 5
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D018975 |
[One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.
] |
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Insulin-Like Growth Factor Binding Protein 6
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D018976 |
[One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.
] |
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Insulin-Like Growth Factor Binding Proteins
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D018969 |
[A family of soluble proteins that bind insulin-like growth factors and modulate their biological actions at the cellular level. (Int J Gynaecol Obstet 1992;39(1):3-9)
] |