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Homer Scaffolding Proteins
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D000072233 |
[Homer proteins belong to a family of adaptor and scaffold proteins which include Homer1, Homer2 and Homer3. Homer1 and Homer2 play a role in the regulation of calcium homeostasis, whereas Homer3 functions in stimulating changes in actin dynamics in neurons and T-cells. Homer proteins are best known as scaffold proteins at the post-synaptic density where they facilitate synaptic signaling. They function as a molecular switch in metabotropic glutamate receptor (MGluR) signaling, and are associated with human Fragile X syndrome.
] |
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Homes for the Aged
|
D006707 |
[Geriatric long-term care facilities which provide supervision and assistance in activities of daily living with medical and nursing services when required.
] |
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Homicide
|
D006708 |
[The killing of one person by another.
] |
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Homing Behavior
|
D006702 |
[Instinctual patterns of activity related to a specific area including ability of certain animals to return to a given place when displaced from it, often over great distances using navigational clues such as those used in migration (ANIMAL MIGRATION).
] |
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Hominidae
|
D015186 |
[An obsolete name for a family of Primates consisting of three genera: Pongo (PONGO PYGMAEUS), Pan (PAN TROGLODYTES and PAN PANISCUS), and Gorilla (GORILLA GORILLA).
, Family of the suborder HAPLORHINI (Anthropoidea) comprising bipedal primate MAMMALS. It includes modern man (HOMO SAPIENS) and the great apes: gorillas (GORILLA GORILLA), chimpanzees (PAN PANISCUS and PAN TROGLODYTES), and orangutans (PONGO PYGMAEUS).
, A tribe (taxon between family and genus) consisting of the line leading to HUMANS after its split from the other African ape lineages. This tribe includes all of the Homo species (HOMO SAPIENS; HOMO NEANDERTHALENSIS; H. ergaster; H. rudolfensis), all of the Australopithecines (Australopithicus africanus, A. boisei, etc.) and other ancient forms like Paranthropus and Ardipithecus.
] |
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Homoarginine
|
D006709 |
|
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Homocysteine
|
D006710 |
[A thiol-containing amino acid formed by a demethylation of METHIONINE.
] |
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Homocysteine S-Methyltransferase
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D050904 |
[An enzyme that catalyzes the demethylation of L-homocysteine to L-METHIONINE.
] |
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Homocystine
|
D006711 |
|
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Homocystinuria
|
D006712 |
[Autosomal recessive inborn error of methionine metabolism usually caused by a deficiency of CYSTATHIONINE BETA-SYNTHASE and associated with elevations of homocysteine in plasma and urine. Clinical features include a tall slender habitus, SCOLIOSIS, arachnodactyly, MUSCLE WEAKNESS, genu varus, thin blond hair, malar flush, lens dislocations, an increased incidence of MENTAL RETARDATION, and a tendency to develop fibrosis of arteries, frequently complicated by CEREBROVASCULAR ACCIDENTS and MYOCARDIAL INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, p979)
] |
|
Homogentisate 1,2-Dioxygenase
|
D050560 |
[A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.
] |
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Homogentisic Acid
|
D006713 |
[Dihydroxyphenylacetic acid with hydroxyls at the 2 and 5 positions of the phenyl ring.
] |
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Homoharringtonine
|
D000077863 |
[Semisynthetic derivative of harringtonine that acts as a protein synthesis inhibitor and induces APOPTOSIS in tumor cells. It is used in the treatment of MYELOID LEUKEMIA, CHRONIC.
] |
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Homologous Recombination
|
D059765 |
[An exchange of DNA between matching or similar sequences.
] |
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Homophobia
|
D063509 |
[Differential treatment or unequal access to opportunities or services based on perceived homosexual preference or orientation.
] |
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Homoserine
|
D006714 |
|
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Homoserine Dehydrogenase
|
D006715 |
[An enzyme that catalyzes the reduction of aspartic beta-semialdehyde to homoserine, which is the branch point in biosynthesis of methionine, lysine, threonine and leucine from aspartic acid. EC 1.1.1.3.
] |
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Homoserine O-Succinyltransferase
|
D051082 |
[The first enzyme in the METHIONINE biosynthetic pathway, this enzyme catalyzes the succinylation reaction of L-homoserine to O-succinyl-L-homoserine and COENZYME A using succinyl-CoA.
] |
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Homosexuality
|
D006716 |
[The sexual attraction or relationship between members of the same SEX.
] |
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Homosexuality, Female
|
D018452 |
[Sexual attraction or relationship between females.
] |
