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Heteroduplex Analysis
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D020180 |
[A method of detecting gene mutation by mixing PCR-amplified mutant and wild-type DNA followed by denaturation and reannealing. The resultant products are resolved by gel electrophoresis, with single base substitutions detectable under optimal electrophoretic conditions and gel formulations. Large base pair mismatches may also be analyzed by using electron microscopy to visualize heteroduplex regions.
] |
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Heterogeneous Nuclear Ribonucleoprotein A1
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D000076245 |
[A heterogeneous ribonucleoprotein that contains an RNA-BINDING MOTIF and has poly(ADP)ribose-binding capability. It functions in the packaging of pre-mRNA into hnRNP particles for export to the cytoplasm and may play a role in RNA SPLICING site selection.
] |
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Heterogeneous Nuclear Ribonucleoprotein D0
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D000081035 |
[Member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) specifically binds RNA molecules that contain AU RICH ELEMENTS found within the 3'-UTR of many PROTO-ONCOGENES and CYTOKINES mRNAs. It functions as a transcription factor, binds to double- and single-stranded DNA sequences in a specific manner.
] |
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Heterogeneous-Nuclear Ribonucleoprotein D
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D034502 |
[A heterogeneous-nuclear ribonucleoprotein that has specificity for AU-rich elements found in the 3'-region of mRNA and may play a role in RNA stability. Several isoforms of hnRNP D protein have been found to occur due to alternative mRNA splicing (RNA SPLICING).
] |
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Heterogeneous-Nuclear Ribonucleoprotein Group A-B
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D034481 |
[A class of closely related heterogeneous-nuclear ribonucleoproteins of approximately 34-40 kDa in size. Although they are generally found in the nucleoplasm, they also shuttle between the nucleus and the cytoplasm. Members of this class have been found to have a role in mRNA transport, telomere biogenesis and RNA SPLICING.
] |
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Heterogeneous-Nuclear Ribonucleoprotein Group C
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D034482 |
[A group of closely related heterogeneous-nuclear ribonucleoproteins of approximately 41-43 kDa in size found in the cell nucleus. Members of this class have been implicated in a variety of processes including splicing, polyadenylation, and nuclear retention of RNA.
] |
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Heterogeneous-Nuclear Ribonucleoprotein Group F-H
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D034541 |
[A group of closely-related heterogeneous-nuclear ribonucleoproteins that are involved in pre-mRNA splicing.
] |
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Heterogeneous-Nuclear Ribonucleoprotein Group M
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D034761 |
[A group of closely-related 72-74-kDa heterogeneous-nuclear ribonucleoproteins that are involved in RNA SPLICING events.
] |
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Heterogeneous-Nuclear Ribonucleoprotein K
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D034641 |
[A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.
] |
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Heterogeneous-Nuclear Ribonucleoprotein L
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D034664 |
[A heterogeneous-nuclear ribonucleoprotein found associated with most nascent transcripts, most notably those of the landmark giant loops of amphibian lampbrush chromosomes.
] |
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Heterogeneous-Nuclear Ribonucleoprotein U
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D034722 |
[A heterogeneous-nuclear ribonucleoprotein found associated with the NUCLEAR MATRIX.
] |
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Heterogeneous-Nuclear Ribonucleoproteins
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D034441 |
[A family of ribonucleoproteins that were originally found as proteins bound to nascent RNA transcripts in the form of ribonucleoprotein particles. Although considered ribonucleoproteins they are primarily classified by their protein component. They are involved in a variety of processes such as packaging of RNA and RNA TRANSPORT within the nucleus. A subset of heterogeneous-nuclear ribonucleoproteins are involved in additional functions such as nucleocytoplasmic transport (ACTIVE TRANSPORT, CELL NUCLEUS) of RNA and mRNA stability in the CYTOPLASM.
] |
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Heterografts
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D064593 |
[Tissues, cells or organs transplanted between animals of different species.
] |
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Heterophyidae
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D006578 |
[A family of intestinal flukes of the class Trematoda which occurs in animals and man. Some of the genera are Heterophyes, Metagonimus, Cryptocotyle, Stellantchasmus, and Euryhelmis.
] |
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Heteroplasmy
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D000081942 |
[Identical organellar GENOMES throughout a population of organelles.
, The occurrence of more than one organellar GENOME in the organelle population of a cell, tissue, or individual organism. It is due to the accumulation of different mutations that occur within the population of individual organelles of a cell.
] |
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Heteroptera
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D020062 |
[A suborder of HEMIPTERA, called true bugs, characterized by the possession of two pairs of wings. It includes the medically important families CIMICIDAE and REDUVIIDAE. (From Dorland, 28th ed)
] |
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Heterosexuality
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D020010 |
[The sexual attraction or relationship between members of the opposite SEX.
] |
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Heterotaxy Syndrome
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D059446 |
[Abnormal thoracoabdominal VISCERA arrangement (visceral heterotaxy) or malformation that involves additional CONGENITAL HEART DEFECTS (e.g., heart isomerism; DEXTROCARDIA) and/or abnormal SPLEEN (e.g., asplenia and polysplenia). Irregularities with the central nervous system, the skeleton and urinary tract are often associated with the syndrome.
, Congenital deformity in which the internal organs of the THORAX and the ABDOMEN are abnormally arranged across the mediolateral body axis.
] |
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Heterotrimeric GTP-Binding Proteins
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D020962 |
[GTP-BINDING PROTEINS that contain three non-identical subunits. They are found associated with members of the seven transmembrane domain superfamily of G-PROTEIN-COUPLED RECEPTORS. Upon activation the GTP-BINDING PROTEIN ALPHA SUBUNIT of the complex dissociates leaving a dimer of a GTP-BINDING PROTEIN BETA SUBUNIT bound to a GTP-BINDING PROTEIN GAMMA SUBUNIT.
] |
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Heterotrophic Processes
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D052836 |
[The processes by which organisms utilize organic substances as their nutrient sources. Contrasts with AUTOTROPHIC PROCESSES which make use of simple inorganic substances as the nutrient supply source. Heterotrophs can be either chemoheterotrophs (or chemoorganotrophs) which also require organic substances such as glucose for their primary metabolic energy requirements, or photoheterotrophs (or photoorganotrophs) which derive their primary energy requirements from light. Depending on environmental conditions some organisms can switch between different nutritional modes (AUTOTROPHY; heterotrophy; chemotrophy; or PHOTOTROPHY) to utilize different sources to meet their nutrients and energy requirements.
] |