|
Hemoglobin C Disease
|
D006445 |
[A disease characterized by compensated hemolysis with a normal hemoglobin level or a mild to moderate anemia. There may be intermittent abdominal discomfort, splenomegaly, and slight jaundice.
] |
|
Hemoglobin E
|
D006446 |
[An abnormal hemoglobin that results from the substitution of lysine for glutamic acid at position 26 of the beta chain. It is most frequently observed in southeast Asian populations.
] |
|
Hemoglobin H
|
D006447 |
[An abnormal hemoglobin composed of four beta chains. It is caused by the reduced synthesis of the alpha chain. This abnormality results in ALPHA-THALASSEMIA.
] |
|
Hemoglobin J
|
D006448 |
[A group of abnormal hemoglobins with similar electrophoretic characteristics. They have faster electrophoretic mobility and different amino acid substitutions in either the alpha or beta chains than normal adult hemoglobin. Some of the variants produce hematologic abnormalities, others result in no clinical disorders.
] |
|
Hemoglobin M
|
D006449 |
[A group of abnormal hemoglobins in which amino acid substitutions take place in either the alpha or beta chains but near the heme iron. This results in facilitated oxidation of the hemoglobin to yield excess methemoglobin which leads to cyanosis.
] |
|
Hemoglobin SC Disease
|
D006450 |
[One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia.
] |
|
Hemoglobin Subunits
|
D055554 |
[The PROTEIN SUBUNITS that comprise multimeric HEMOGLOBINS.
] |
|
Hemoglobin, Sickle
|
D006451 |
[An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
] |
|
Hemoglobinometry
|
D006452 |
[Measurement of hemoglobin concentration in blood.
] |
|
Hemoglobinopathies
|
D006453 |
[A group of inherited disorders characterized by structural alterations within the hemoglobin molecule.
] |
|
Hemoglobins
|
D006454 |
[The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
] |
|
Hemoglobins, Abnormal
|
D006455 |
[Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.
] |
|
Hemoglobinuria
|
D006456 |
[The presence of free HEMOGLOBIN in the URINE, indicating hemolysis of ERYTHROCYTES within the vascular system. After saturating the hemoglobin-binding proteins (HAPTOGLOBINS), free hemoglobin begins to appear in the urine.
] |
|
Hemoglobinuria, Paroxysmal
|
D006457 |
[A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.
] |
|
Hemolymph
|
D006458 |
[The blood/lymphlike nutrient fluid of some invertebrates.
] |
|
Hemolysin Factors
|
D006459 |
[Plasmids controlling the synthesis of hemolysin by bacteria.
] |
|
Hemolysin Proteins
|
D006460 |
[Proteins from BACTERIA and FUNGI that are soluble enough to be secreted to target ERYTHROCYTES and insert into the membrane to form beta-barrel pores. Biosynthesis may be regulated by HEMOLYSIN FACTORS.
] |
|
Hemolysis
|
D006461 |
[The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
] |
|
Hemolytic Agents
|
D053878 |
[Substances that are toxic to blood in general, including the clotting mechanism; hematotoxins may refer to the hematopoietic system.
] |
|
Hemolytic Plaque Technique
|
D006462 |
[A method to identify and enumerate cells that are synthesizing ANTIBODIES against ANTIGENS or HAPTENS conjugated to sheep RED BLOOD CELLS. The sheep red blood cells surrounding cells secreting antibody are lysed by added COMPLEMENT producing a clear zone of HEMOLYSIS. (From Illustrated Dictionary of Immunology, 3rd ed)
] |
