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Genetic Diseases, Inborn
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D030342 |
[Diseases caused by genetic mutations that are inherited from a parent's genome.
, Diseases that are caused by genetic mutations present during embryo or fetal development, although they may be observed later in life. The mutations may be inherited from a parent's genome or they may be acquired in utero.
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Genetic Diseases, X-Linked
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D040181 |
[Genetic diseases that are linked to gene mutations on the X CHROMOSOME in humans (X CHROMOSOME, HUMAN) or the X CHROMOSOME in other species. Included here are animal models of human X-linked diseases.
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Genetic Diseases, Y-Linked
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D050174 |
[Genetic diseases that are linked to mutant ALLELES on the Y CHROMOSOME in humans (Y CHROMOSOME, HUMAN) or the Y chromosome in other species. Included here are animal models of human Y-linked diseases.
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Genetic Drift
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D040961 |
[The fluctuation of the ALLELE FREQUENCY from one generation to the next.
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Genetic Engineering
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D005818 |
[Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.
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Genetic Enhancement
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D024861 |
[The use of genetic methodologies to improve functional capacities of an organism rather than to treat disease.
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Genetic Fitness
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D056084 |
[The relative likelihood that an organism will survive and pass on its genes to the next generation in comparison to organisms with a different gene or genotype. It is a mathematically calculable ratio determined from the average number of offspring contributed to a population by a particular genotype during one generation compared to the average number of offspring contributed by competing genotypes.
, Genetic fitness measured as growth rate or reproductive success which is characterized by parameters such as egg production capacity, fertility, and number of offspring that pass on their genes.
, The capability of an organism to survive and reproduce. The phenotypic expression of the genotype in a particular environment determines how genetically fit an organism will be.
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Genetic Heterogeneity
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D018740 |
[The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are involved in different pedigrees. In clinical settings genetic heterogeneity refers to the presence of a variety of genetic defects which cause the same disease, often due to mutations at different loci on the same gene, a finding common to many human diseases including ALZHEIMER DISEASE; CYSTIC FIBROSIS; LIPOPROTEIN LIPASE DEFICIENCY, FAMILIAL; and POLYCYSTIC KIDNEY DISEASES. (Rieger, et al., Glossary of Genetics: Classical and Molecular, 5th ed; Segen, Dictionary of Modern Medicine, 1992)
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Genetic Introgression
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D000079425 |
[The transfer of genetic material from one species to another by inter-species hybridization and repeated backcrossing.
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Genetic Linkage
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D008040 |
[The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
, The determination of the physical association and distance between of two or more non-allelic GENES by measuring their co-inheritance or mapping their physical location on the same CHROMOSOME.
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Genetic Load
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D040741 |
[The relative amount by which the average fitness of a POPULATION is lowered, due to the presence of GENES that decrease survival, compared to the GENOTYPE with maximum or optimal fitness. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
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Genetic Loci
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D056426 |
[Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.
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Genetic Markers
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D005819 |
[A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.
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Genetic Phenomena
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D055614 |
[The biological processes, properties, and objects that are involved in maintaining, expressing, and transmitting from one organism to another, genetically encoded traits.
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Genetic Pleiotropy
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D058685 |
[A single gene that influences several distinct and seemly unrelated phenotypic outcomes.
, A phenomenon in which multiple and diverse phenotypic outcomes are influenced by a single gene (or single gene product.)
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Genetic Predisposition to Disease
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D020022 |
[A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
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Genetic Privacy
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D030661 |
[The protection of genetic information about an individual, family, or population group, from unauthorized disclosure.
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Genetic Profile
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D000076610 |
[A set of characteristics unique to the DNA of an individual organism or population obtained by analyzing small samples of biological material such as body tissues or fluids, used especially in the context of predicting susceptibility to a particular disease. For example, some populations have identifiable genetic profiles which put them at higher risk for cancer. Distinguish from GENETIC BACKGROUND and GENETIC VARIATION.
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Genetic Research
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D036281 |
[Research into the cause, transmission, amelioration, elimination, or enhancement of inherited disorders and traits.
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Genetic Services
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D033142 |
[Organized services to provide diagnosis, treatment, and prevention of genetic disorders.
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