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Genes, Protozoan
|
D017125 |
[The functional hereditary units of protozoa.
] |
|
Genes, RAG-1
|
D016654 |
[Genes involved in activating the enzyme VDJ recombinase. RAG-1 is located on chromosome 11 in humans (chromosome 2 in mice) and is expressed exclusively in maturing lymphocytes.
] |
|
Genes, Recessive
|
D005808 |
[Genes that influence the PHENOTYPE only in the homozygous state.
] |
|
Genes, Regulator
|
D005809 |
[Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.
] |
|
Genes, Reporter
|
D017930 |
[Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.
] |
|
Genes, Retinoblastoma
|
D016161 |
[Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kDa to 115 kDa. One copy of the wild-type Rb gene is necessary for normal retinal development. Loss or inactivation of both alleles at this locus results in retinoblastoma.
] |
|
Genes, Suppressor
|
D016153 |
[Genes that have a suppressor allele or suppressor mutation (SUPPRESSION, GENETIC) which cancels the effect of a previous mutation, enabling the wild-type phenotype to be maintained or partially restored. For example, amber suppressors cancel the effect of an AMBER NONSENSE MUTATION.
] |
|
Genes, Switch
|
D005812 |
[Genes that cause the epigenotype (i.e., the interrelated developmental pathways through which the adult organism is realized) to switch to an alternate cell lineage-related pathway. Switch complexes control the expression of normal functional development as well as oncogenic transformation.
] |
|
Genes, Synthetic
|
D005813 |
[Biologically functional sequences of DNA chemically synthesized in vitro.
] |
|
Genes, T-Cell Receptor
|
D019672 |
[DNA sequences, in cells of the T-lymphocyte lineage, that code for T-cell receptors. The TcR genes are formed by somatic rearrangement (see GENE REARRANGEMENT, T-LYMPHOCYTE and its children) of germline gene segments, and resemble Ig genes in their mechanisms of diversity generation and expression.
] |
|
Genes, T-Cell Receptor alpha
|
D019673 |
[DNA sequences encoding the alpha chain of the T-cell receptor. The genomic organization of the TcR alpha genes is essentially the same in all species and is similar to the organization of Ig genes.
] |
|
Genes, T-Cell Receptor beta
|
D019674 |
[DNA sequences encoding the beta chain of the T-cell receptor. The genomic organization of the TcR beta genes is essentially the same in all species and is similar to the organization of Ig genes.
] |
|
Genes, T-Cell Receptor delta
|
D019676 |
[DNA sequences encoding the delta chain of the T-cell receptor. The delta-chain locus is located entirely within the alpha-chain locus.
] |
|
Genes, T-Cell Receptor gamma
|
D019675 |
[DNA sequences encoding the gamma chain of the T-cell receptor. The human gamma-chain locus is organized similarly to the TcR beta-chain locus.
] |
|
Genes, Transgenic, Suicide
|
D041722 |
[Transgenes encoding enzymes which can convert non-toxic PRODRUGS into cytotoxic metabolites, thereby inducing CELL DEATH.
, Genes that are used transgenically, i.e., via GENE TRANSFER TECHNIQUES to induce CELL DEATH.
] |
|
Genes, Tumor Suppressor
|
D016147 |
[Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
] |
|
Genes, Viral
|
D005814 |
[The functional hereditary units of VIRUSES.
] |
|
Genes, Wilms Tumor
|
D016162 |
[Genes located at on the short arm of chromosome 11, at band p15 whose absence is associated with the formation of Wilms tumor. This Wilms tumor locus is also associated with BECKWITH-WIEDEMANN SYNDROME.
, Genes at loci that are involved in the development of WILMS TUMOR. Included are human WT1 at 11p13 and human WT2 (MTACR1) at 11p15.
, Tumor suppressor gene located in the 11p13 region on the short arm of human chromosome 11. The absence of this gene is associated with the formation of Wilms tumor. It encodes several isoforms that are zinc finger containing transcription factors involved in both transactivation and repression, and are critical for normal development and function of the urogenital tract.
] |
|
Genes, X-Linked
|
D050172 |
[Genes that are located on the X CHROMOSOME.
] |
|
Genes, Y-Linked
|
D050173 |
[Genes that are located on the Y CHROMOSOME.
] |
