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ELAV-Like Protein 1
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D000067780 |
[An RRM protein that binds to the 3'-UTR region of mRNAs and increases their stability. In EMBRYONIC STEM CELLS, it binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs and preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), to stabilize them and promote differentiation.
] |
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ELAV-Like Protein 2
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D000067777 |
[A neural-specific RRM protein that binds to several 3'UTRs, including its own as well as that of PROTO-ONCOGENE PROTEINS C-FOS and ID DNA BINDING PROTEIN INHIBITOR. It binds through the recognition of a GAAA motif in the RNAs.
] |
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ELAV-Like Protein 3
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D000067778 |
[A neural-specific RRM protein which contains three RNP-type RNA recognition motifs (RRMs). Human ELAVL3 is recognized by the anti-Hu serum antibody from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN). It also functions in neurogenesis.
] |
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ELAV-Like Protein 4
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D000067779 |
[An RRM protein which binds AU-rich sequences in the 3' UNTRANSLATED REGIONS of mRNAs for PROTO-ONCOGENE PROTEINS C-FOS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; and GAP-43 PROTEIN. It functions in neuron-specific RNA processing.
] |
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ERG1 Potassium Channel
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D000072237 |
[One of three members of the ether-a-go-go (EAG) POTASSIUM CHANNELS gene family comprising ether-a-go-go (eag), eag-like (elk) and eag-related (erg) subfamilies. Ether-a-go-go-related gene 1 (ERG1) also known as KCNH2, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel that plays an essential role in the final repolarization of ventricular action potential. Loss-of-function mutations in human hERG1 is associated with life-threatening ARRHYTHMIA.
] |
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ETS Motif
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D000071419 |
[A helix-turn-helix motif characterized by three alpha-helices and four-stranded beta-sheets arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4. The third alpha-helix contacts the major groove of DNA. The ETS motif and the flanking amino acid sequences of Ets proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificity.
] |
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Eagles
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D020307 |
[Large members of the FALCONIFORMES order of birds, family Accipitridae, most especially the genera Aquila, Haliaeetus, Harpia, and Circaetus. They are characterized by their powerful talons, which carry long, curved, pointed claws and by their opposable hindtoe.
] |
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Ear
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D004423 |
[The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE.
] |
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Ear Auricle
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D054644 |
[The shell-like structure projects like a little wing (pinna) from the side of the head. Ear auricles collect sound from the environment.
] |
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Ear Canal
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D004424 |
[The narrow passage way that conducts the sound collected by the EAR AURICLE to the TYMPANIC MEMBRANE.
] |
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Ear Cartilage
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D004425 |
[Cartilage of the EAR AURICLE and the EXTERNAL EAR CANAL.
] |
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Ear Deformities, Acquired
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D004426 |
[Distortion or disfigurement of the ear caused by disease or injury after birth.
] |
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Ear Diseases
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D004427 |
[Pathological processes of the ear, the hearing, and the equilibrium system of the body.
] |
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Ear Neoplasms
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D004428 |
[Tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR).
] |
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Ear Ossicles
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D004429 |
[A mobile chain of three small bones (INCUS; MALLEUS; STAPES) in the TYMPANIC CAVITY between the TYMPANIC MEMBRANE and the oval window on the wall of INNER EAR. Sound waves are converted to vibration by the tympanic membrane then transmitted via these ear ossicles to the inner ear.
] |
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Ear Protective Devices
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D004430 |
[Personal devices for protection of the ears from loud or high intensity noise, water, or cold. These include earmuffs and earplugs.
] |
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Ear, External
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D004431 |
[The outer part of the hearing system of the body. It includes the shell-like EAR AURICLE which collects sound, and the EXTERNAL EAR CANAL, the TYMPANIC MEMBRANE, and the EXTERNAL EAR CARTILAGES.
] |
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Ear, Inner
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D007758 |
[The essential part of the hearing organ consists of two labyrinthine compartments: the bony labyrinthine and the membranous labyrinth. The bony labyrinth is a complex of three interconnecting cavities or spaces (COCHLEA; VESTIBULAR LABYRINTH; and SEMICIRCULAR CANALS) in the TEMPORAL BONE. Within the bony labyrinth lies the membranous labyrinth which is a complex of sacs and tubules (COCHLEAR DUCT; SACCULE AND UTRICLE; and SEMICIRCULAR DUCTS) forming a continuous space enclosed by EPITHELIUM and connective tissue. These spaces are filled with LABYRINTHINE FLUIDS of various compositions.
] |
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Ear, Middle
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D004432 |
[The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat.
] |
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Earache
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D004433 |
[Pain in the ear.
] |
