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DNA, Ribosomal Spacer
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D021903 |
[The intergenic DNA segments that are between the ribosomal RNA genes (internal transcribed spacers) and between the tandemly repeated units of rDNA (external transcribed spacers and nontranscribed spacers).
] |
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DNA, Satellite
|
D004276 |
[Highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres. They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated in tandem many times to form large blocks of sequence. Additionally, following the accumulation of mutations, these blocks of repeats have been repeated in tandem themselves. The degree of repetition is on the order of 1000 to 10 million at each locus. Loci are few, usually one or two per chromosome. They were called satellites since in density gradients, they often sediment as distinct, satellite bands separate from the bulk of genomic DNA owing to a distinct BASE COMPOSITION.
] |
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DNA, Single-Stranded
|
D004277 |
[A single chain of deoxyribonucleotides that occurs in some bacteria and viruses. It usually exists as a covalently closed circle.
] |
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DNA, Superhelical
|
D004278 |
[Circular duplex DNA isolated from viruses, bacteria and mitochondria in supercoiled or supertwisted form. This superhelical DNA is endowed with free energy. During transcription, the magnitude of RNA initiation is proportional to the DNA superhelicity.
] |
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DNA, Viral
|
D004279 |
[Deoxyribonucleic acid that makes up the genetic material of viruses.
] |
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DNA, Z-Form
|
D043542 |
[A left-handed double helix of DNA. Its name derives from its narrow zigzag structure that is the least twisted and thinnest form of DNA. Z-DNA forming regions within the GENOME may play an important role in GENE EXPRESSION REGULATION.
] |
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DNA-(Apurinic or Apyrimidinic Site) Lyase
|
D043603 |
[A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
] |
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DNA-Activated Protein Kinase
|
D051747 |
[A serine-threonine protein kinase that, when activated by DNA, phosphorylates several DNA-binding protein substrates including the TUMOR SUPPRESSOR PROTEIN P53 and a variety of TRANSCRIPTION FACTORS.
] |
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DNA-Binding Proteins
|
D004268 |
[Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
] |
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DNA-Cytosine Methylases
|
D015257 |
[Methylases that are specific for CYTOSINE residues found on DNA.
, Enzymes responsible for producing a species-specific methylation pattern on cytosine residues.
] |
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DNA-Directed DNA Polymerase
|
D004259 |
[DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
] |
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DNA-Directed RNA Polymerases
|
D012321 |
[Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).
] |
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DNA-Formamidopyrimidine Glycosylase
|
D043382 |
[A DNA repair enzyme that is an N-glycosyl hydrolase with specificity for DNA-containing ring-opened N(7)-methylguanine residues.
] |
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Dabigatran
|
D000069604 |
[A THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.
] |
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Dacarbazine
|
D003606 |
[An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
] |
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Daclizumab
|
D000077561 |
[An anti-TAC (INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT) humanized monoclonal antibody (immunoglobulin G1 disulfide with human-mouse monoclonal clone 1H4 light chain, dimer) that is used in the treatment of ACUTE RELAPSING MULTIPLE SCLEROSIS.
] |
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Dacryocystitis
|
D003607 |
[Inflammation of the lacrimal sac. (Dorland, 27th ed)
] |
|
Dacryocystorhinostomy
|
D003608 |
[Surgical fistulization of the LACRIMAL SAC for external drainage of an obstructed nasolacrimal duct.
] |
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Dactinomycin
|
D003609 |
[A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
] |
|
Dactylis
|
D031745 |
[A plant genus of the family POACEAE that contains allergen Dac g I.
] |
