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Chromosome Fragile Sites
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D043283 |
[Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)
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Chromosome Fragility
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D002873 |
[Susceptibility of chromosomes to breakage leading to translocation; CHROMOSOME INVERSION; SEQUENCE DELETION; or other CHROMOSOME BREAKAGE related aberrations.
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Chromosome Inversion
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D007446 |
[An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation, so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome.
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Chromosome Mapping
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D002874 |
[Any method used for determining the location of and relative distances between genes on a chromosome.
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Chromosome Painting
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D020223 |
[A technique for visualizing CHROMOSOME ABERRATIONS using fluorescently labeled DNA probes which are hybridized to chromosomal DNA. Multiple fluorochromes may be attached to the probes. Upon hybridization, this produces a multicolored, or painted, effect with a unique color at each site of hybridization. This technique may also be used to identify cross-species homology by labeling probes from one species for hybridization with chromosomes from another species.
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Chromosome Pairing
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D023902 |
[The alignment of CHROMOSOMES at homologous sequences.
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Chromosome Positioning
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D045584 |
[The mechanisms of eukaryotic CELLS that place or keep the CHROMOSOMES in a particular SUBNUCLEAR SPACE.
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Chromosome Segregation
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D020090 |
[The orderly segregation of CHROMOSOMES during MEIOSIS or MITOSIS.
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Chromosome Structures
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D022004 |
[Structures which are contained in or part of CHROMOSOMES.
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Chromosome Walking
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D016386 |
[A technique with which an unknown region of a chromosome can be explored. It is generally used to isolate a locus of interest for which no probe is available but that is known to be linked to a gene which has been identified and cloned. A fragment containing a known gene is selected and used as a probe to identify other overlapping fragments which contain the same gene. The nucleotide sequences of these fragments can then be characterized. This process continues for the length of the chromosome.
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Chromosomes
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D002875 |
[In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
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Chromosomes, Archaeal
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D019847 |
[Structures within the nucleus of archaeal cells consisting of or containing DNA, which carry genetic information essential to the cell.
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Chromosomes, Artificial
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D022201 |
[DNA constructs that are composed of, at least, elements such as a REPLICATION ORIGIN; TELOMERE; and CENTROMERE, that are required for successful replication, propagation to and maintenance in progeny cells. In addition, they are constructed to carry other sequences for analysis or gene transfer.
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Chromosomes, Artificial, Bacterial
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D022202 |
[DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.
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Chromosomes, Artificial, Human
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D022222 |
[DNA constructs that are composed of, at least, all elements, such as a REPLICATION ORIGIN; TELOMERE; and CENTROMERE, required for successful replication, propagation to and maintainance in progeny human cells. In addition, they are constructed to carry other sequences for analysis or gene transfer.
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Chromosomes, Artificial, Mammalian
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D022221 |
[DNA constructs that are composed of, at least, all elements, such as a REPLICATION ORIGIN; TELOMERE; and CENTROMERE, that are required for successful replication, propagation to and maintainance in progeny mammalian cells. In addition, they are constructed to carry other sequences for analysis or gene transfer.
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Chromosomes, Artificial, P1 Bacteriophage
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D027042 |
[DNA constructs that are derived from the DNA of BACTERIOPHAGE P1. They can carry large amounts (about 100-300 kilobases) of other sequence for a variety of bioengineering purposes.
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Chromosomes, Artificial, Yeast
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D018244 |
[Chromosomes in which fragments of exogenous DNA ranging in length up to several hundred kilobase pairs have been cloned into yeast through ligation to vector sequences. These artificial chromosomes are used extensively in molecular biology for the construction of comprehensive genomic libraries of higher organisms.
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Chromosomes, Bacterial
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D002876 |
[Structures within the nucleus of bacterial cells consisting of or containing DNA, which carry genetic information essential to the cell.
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Chromosomes, Fungal
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D015825 |
[Structures within the nucleus of fungal cells consisting of or containing DNA, which carry genetic information essential to the cell.
] |
