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Tumor Suppressor Protein p14ARF
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D025803 |
[A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of MDM2 PROTEIN (which regulates P53 TUMOR SUPPRESSOR PROTEIN by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is CYCLIN-DEPENDENT KINASE INHIBITOR P16. Both p16 gene products have tumor suppressor functions.
] |
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Tumor Suppressor Protein p53
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D016159 |
[Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
] |
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Tumor Suppressor Proteins
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D025521 |
[Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
] |
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Tumor Suppressor p53-Binding Protein 1
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D000071857 |
[A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.
] |
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Tumor Virus Infections
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D014412 |
[Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.
] |
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Tumor-Associated Macrophages
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D000084582 |
[Various macrophages found in TUMOR MICROENVIRONMENT. They may interact with tumor cells to influence growth and NEOPLASTIC PROCESSES.
] |
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Tuna
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D014413 |
[Common name for various species of large, vigorous ocean fishes in the family Scombridae.
] |
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Tundra
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D065929 |
[An ecosystem dominated by grasses, lichens, mosses, sedges and shrubs in cold landscapes or at high elevations where a layer of the ground remains perennially frozen (PERMAFROST).
] |
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Tunga
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D058253 |
[A genus of parasitic fleas in the family Pulicidae. They are found mainly in Africa, South America, and Central America.
, A species of burrowing flea that requires a human host or other mammal to reproduce.
] |
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Tungiasis
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D058285 |
[An infestation with the flea TUNGA PENETRANS causing inflammation, pruritus, and pain, in both humans and other mammals. There is a high incidence of secondary infections such as BACTEREMIA and TETANUS.
] |
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Tungrovirus
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D052641 |
[A genus of DNA plant viruses of the family CAULIMOVIRIDAE. The sole species, Rice tungro bacilliform virus, shows 25% identity with BADNAVIRUS. It is transmitted by leafhoppers with the assistance of RICE TUNGRO SPHERICAL VIRUS.
] |
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Tungsten
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D014414 |
[A metallic element with the atomic symbol W, atomic number 74, and atomic weight 183.85. It is used in many manufacturing applications, including increasing the hardness, toughness, and tensile strength of steel; manufacture of filaments for incandescent light bulbs; and in contact points for automotive and electrical apparatus.
] |
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Tungsten Compounds
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D017973 |
[Inorganic compounds that contain tungsten as an integral part of the molecule.
] |
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Tunica Intima
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D017539 |
[The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
] |
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Tunica Media
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D017540 |
[The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.
] |
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Tunicamycin
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D014415 |
[An N-acetylglycosamine containing antiviral antibiotic obtained from Streptomyces lysosuperificus. It is also active against some bacteria and fungi, because it inhibits the glucosylation of proteins. Tunicamycin is used as tool in the study of microbial biosynthetic mechanisms.
] |
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Tunisia
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D014416 |
[A country in northern Africa between ALGERIA and LIBYA. Its capital is Tunis.
] |
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Tupaia
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D014417 |
[A genus of tree shrews of the family TUPAIIDAE which consists of about 12 species. One of the most frequently encountered species is T. glis. Members of this genus inhabit rain forests and secondary growth areas in southeast Asia.
] |
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Tupaiidae
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D014418 |
[The only family of the order SCANDENTIA, variously included in the order Insectivora or in the order Primates, and often in the order Microscelidea, consisting of five genera. They are TUPAIA, Ananthana (Indian tree shrew), Dendrogale (small smooth-tailed tree shrew), Urogale (Mindanao tree shrew), and Ptilocercus (pen-tailed tree shrew). The tree shrews inhabit the forest areas of eastern Asia from India and southwestern China to Borneo and the Philippines.
] |
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Turbellaria
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D014419 |
[A class of free-living freshwater flatworms of North America.
] |
