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Tuberculosis, Ocular
|
D014392 |
[Tuberculous infection of the eye, primarily the iris, ciliary body, and choroid.
] |
|
Tuberculosis, Oral
|
D014393 |
[Tuberculosis of the mouth, tongue, and salivary glands.
] |
|
Tuberculosis, Osteoarticular
|
D014394 |
[Tuberculosis of the bones or joints.
] |
|
Tuberculosis, Pleural
|
D014396 |
[Tuberculosis of the serous membrane lining the thoracic cavity and surrounding the lungs.
] |
|
Tuberculosis, Pulmonary
|
D014397 |
[MYCOBACTERIUM infections of the lung.
] |
|
Tuberculosis, Renal
|
D014398 |
[Infection of the KIDNEY with species of MYCOBACTERIUM.
] |
|
Tuberculosis, Spinal
|
D014399 |
[Osteitis or caries of the vertebrae, usually occurring as a complication of tuberculosis of the lungs.
] |
|
Tuberculosis, Splenic
|
D014400 |
[Infection of the spleen with species of MYCOBACTERIUM.
] |
|
Tuberculosis, Urogenital
|
D014401 |
[A general term for MYCOBACTERIUM infections of any part of the UROGENITAL SYSTEM in either the male or the female.
] |
|
Tuberous Sclerosis
|
D014402 |
[Autosomal dominant neurocutaneous syndrome classically characterized by MENTAL RETARDATION; EPILEPSY; and skin lesions (e.g., adenoma sebaceum and hypomelanotic macules). There is, however, considerable heterogeneity in the neurologic manifestations. It is also associated with cortical tuber and HAMARTOMAS formation throughout the body, especially the heart, kidneys, and eyes. Mutations in two loci TSC1 and TSC2 that encode hamartin and tuberin, respectively, are associated with the disease.
, Facial ANGIOFIBROMA in tuberous sclerosis
] |
|
Tuberous Sclerosis Complex 1 Protein
|
D000077004 |
[An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively regulate MTORC1 signaling and affect cell growth and proliferation. Structurally, it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil domain and ezrin-radixin-moesin (ERM) domain. Mutations in the TSC1 gene are associated with TUBEROUS SCLEROSIS.
] |
|
Tuberous Sclerosis Complex 2 Protein
|
D000077005 |
[An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN (TSC1) and other signaling factors to negatively regulate MTORC1 and affect cell growth and proliferation. It can also function as GTPASE-ACTIVATING PROTEIN (GAP) for RHEB GTPASE to activate mTORC1 independent of its role in the complex. Structurally, it interacts with TSC1 through its N-terminus, which also contains a leucine zipper and coiled-coil region. It also has multiple phosphorylation sites for different cell signaling kinases, a central coiled-coil region, a C-terminal GAP domain and CALMODULIN binding domain. Mutations in the TSC2 gene are associated with TUBEROUS SCLEROSIS.
] |
|
Tubocurarine
|
D014403 |
[A neuromuscular blocker and active ingredient in CURARE; plant based alkaloid of Menispermaceae.
] |
|
Tubular Sweat Gland Adenomas
|
D000074009 |
[Various tubular forms of benign tumors of the SWEAT GLAND with glandular differentiation. Common types include syringocystadenoma papilliferum of the head and neck, and hidradenoma papilliferum of the vulva area. Hidradenoma papilliferum may be derived from mammary-like glands of the vulva.
] |
|
Tubulin
|
D014404 |
[A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.
] |
|
Tubulin Modulators
|
D050257 |
[Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.
] |
|
Tubulina
|
D016846 |
[A suborder of ameboid protozoa characterized by a branched or unbranched cylindrical body and the absence of bidirectional cytoplasmic flow. Nuclear division is mesomitotic.
] |
|
Tudor Domain
|
D000071856 |
[A conserved, approximately 50 amino acid, protein sequence that adopts a characteristic strongly bent, five stranded anti-parallel beta-sheet barrel-like fold. The Tudor domain recognizes dimethylated ARGININE through its negatively-charged surface and occurs in many proteins that co-localize with RNA; RIBONUCLEOPROTEINS or SINGLE-STRANDED DNA complexes in the CELL NUCLEUS; MITOCHONDRIA; or KINETOCHORES.
] |
|
Tuftsin
|
D014405 |
[N(2)-((1-(N(2)-L-Threonyl)-L-lysyl)-L-prolyl)-L-arginine. A tetrapeptide produced in the spleen by enzymatic cleavage of a leukophilic gamma-globulin. It stimulates the phagocytic activity of blood polymorphonuclear leukocytes and neutrophils in particular. The peptide is located in the Fd fragment of the gamma-globulin molecule.
] |
|
Tularemia
|
D014406 |
[A plague-like disease of rodents, transmissible to man. It is caused by FRANCISELLA TULARENSIS and is characterized by fever, chills, headache, backache, and weakness.
] |