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Trimethylsilyl Compounds
|
D014297 |
[Organic silicon derivatives used to characterize hydroxysteroids, nucleosides, and related compounds. Trimethylsilyl esters of amino acids are used in peptide synthesis.
] |
|
Trimethyltin Compounds
|
D014298 |
[Organic compounds composed of tin and three methyl groups. Affect mitochondrial metabolism and inhibit oxidative phosphorylation by acting directly on the energy conserving processes.
] |
|
Trimetrexate
|
D016597 |
[A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
] |
|
Trimipramine
|
D014299 |
[Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties.
] |
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Trinidad and Tobago
|
D014300 |
[An independent state in the Lesser Antilles in the West Indies, north of Venezuela, comprising the islands of Trinidad and Tobago. Its capital is Port of Spain. Both islands were discovered by Columbus in 1498. The Spanish, English, Dutch, and French figure in their history over four centuries. Trinidad and Tobago united in 1898 and were made part of the British colony of Trinidad and Tobago in 1899. The colony became an independent state in 1962. Trinidad was so named by Columbus either because he arrived on Trinity Sunday or because three mountain peaks suggested the Holy Trinity. Tobago was given the name by Columbus from the Haitian tambaku, pipe, from the natives' habit of smoking tobacco leaves. (Webster's New Geographical Dictionary, 1988, p1228, 1216 & Room, Brewer's Dictionary of Names, 1992, p555, 547)
] |
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Trinitrobenzenes
|
D014301 |
[Benzene derivatives which are substituted with three nitro groups in any position.
] |
|
Trinitrobenzenesulfonic Acid
|
D014302 |
[A reagent that is used to neutralize peptide terminal amino groups.
] |
|
Trinitrotoluene
|
D014303 |
[A 2,4,6-trinitrotoluene, which is an explosive chemical that can cause skin irritation and other toxic consequences.
] |
|
Trinucleotide Repeat Expansion
|
D019680 |
[An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs.
] |
|
Trinucleotide Repeats
|
D018911 |
[Microsatellite repeats consisting of three nucleotides dispersed in the euchromatic arms of chromosomes.
] |
|
Triolein
|
D014304 |
[(Z)-9-Octadecenoic acid 1,2,3-propanetriyl ester.
] |
|
Triose Sugar Alcohols
|
D000073999 |
[Sugar alcohol molecules that contain three carbons.
] |
|
Triose-Phosphate Isomerase
|
D014305 |
[An enzyme that catalyzes reversibly the conversion of D-glyceraldehyde 3-phosphate to dihydroxyacetone phosphate. A deficiency in humans causes nonspherocytic hemolytic disease (ANEMIA, HEMOLYTIC, CONGENITAL NONSPHEROCYTIC). EC 5.3.1.1.
] |
|
Trioses
|
D014306 |
[Monosaccharide molecules that contain a three carbon backbone.
] |
|
Trioxsalen
|
D014307 |
[Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
] |
|
Triparanol
|
D014308 |
[Antilipemic agent with high ophthalmic toxicity. According to Merck Index, 11th ed, the compound was withdrawn from the market in 1962 because of its association with the formation of irreversible cataracts.
] |
|
Tripartite Motif Proteins
|
D000070584 |
[A protein family defined by the presence of three ZINC FINGER domains, one of which is a RING FINGER DOMAIN, a coiled-coil region, and a highly variable C-terminal region. They function in many cellular processes including APOPTOSIS and CELL CYCLE regulation.
] |
|
Tripartite Motif-Containing Protein 28
|
D000076183 |
[A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.
] |
|
Tripelennamine
|
D014309 |
[A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.
] |
|
Triple Negative Breast Neoplasms
|
D064726 |
[Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.
] |
