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Transforming Growth Factor alpha
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D016211 |
[An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.
] |
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Transforming Growth Factor beta
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D016212 |
[A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
] |
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Transforming Growth Factor beta1
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D053773 |
[A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
] |
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Transforming Growth Factor beta2
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D053781 |
[A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
] |
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Transforming Growth Factor beta3
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D053782 |
[A TGF-beta subtype that plays role in regulating epithelial-mesenchymal interaction during embryonic development. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta3 and TGF-beta3 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
] |
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Transforming Growth Factors
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D015291 |
[Hormonally active polypeptides that can induce the transformed phenotype when added to normal, non-transformed cells. They have been found in culture fluids from retrovirally transformed cells and in tumor-derived cells as well as in non-neoplastic sources. Their transforming activities are due to the simultaneous action of two otherwise unrelated factors, TRANSFORMING GROWTH FACTOR ALPHA and TRANSFORMING GROWTH FACTOR BETA.
] |
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Transfusion Medicine
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D064826 |
[The area of hematology that is concerned with the transfusion of blood and blood components, and in prevention and treatment of adverse effects from BLOOD TRANSFUSION errors.
] |
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Transfusion Reaction
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D065227 |
[Complications of BLOOD TRANSFUSION. Included adverse reactions are common allergic and febrile reactions; hemolytic (delayed and acute) reactions; and other non-hemolytic adverse reactions such as infections and adverse immune reactions related to immunocompatibility.
, Transfusion reaction complications such as delayed suppression of ERYTHROPOIESIS may occur after destruction of autologous RED BLOOD CELLS in Hemolytic Transfusion Reaction.
] |
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Transfusion-Related Acute Lung Injury
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D000073617 |
[A rare but serious transfusion-related reaction in which fluid builds up in the lungs unrelated to excessively high infusion rate and/or volume (TRANSFUSION-ASSOCIATED CIRCULATORY OVERLOAD). Signs of Transfusion-Related Acute Lung Injury include pulmonary secretions; hypotension; fever; DYSPNEA; TACHYPNEA; TACHYCARDIA; and CYANOSIS.
] |
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Transgender Persons
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D063106 |
[Persons having a sense of persistent identification with, and expression of, gender-coded behaviors not typically associated with one's anatomical sex at birth, with or without a desire to undergo SEX REASSIGNMENT PROCEDURES.
, Those individuals with gender dysphoria and with a persistent desire to undergo SEX REASSIGNMENT PROCEDURES.
] |
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Transgenes
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D019076 |
[Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.
] |
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Transglutaminases
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D011503 |
[Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.
] |
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Transient Receptor Potential Channels
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D050051 |
[A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN REPEATS are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
] |
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Transient Tachypnea of the Newborn
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D059245 |
[Abnormal increase in RESPIRATORY RATE in the newborn. It is self-limiting and attributed to the delayed fetal lung fluid clearance often in CAESAREAN SECTION delivery.
] |
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Transients and Migrants
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D014171 |
[People who frequently change their place of residence.
] |
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Transillumination
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D014172 |
[Passage of light through body tissues or cavities for examination of internal structures.
] |
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Transistors, Electronic
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D014173 |
[Electrical devices that are composed of semiconductor material, with at least three connections to an external electronic circuit. They are used to amplify electrical signals, detect signals, or as switches.
] |
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Transition Elements
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D028561 |
[Elements with partially filled d orbitals. They constitute groups 3-12 of the periodic table of elements.
] |
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Transition Temperature
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D044366 |
[The temperature at which a substance changes from one state or conformation of matter to another.
] |
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Transition to Adult Care
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D060305 |
[Transfer from pediatric to adult care.
] |
