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TNF Receptor-Associated Factor 5
|
D048015 |
[A signal transducing tumor necrosis factor receptor associated factor that mediates signaling from CD27 ANTIGENS; CD40 ANTIGENS; and the LYMPHOTOXIN BETA RECEPTOR. It is involved in regulation of NF-KAPPA B signaling.
] |
|
TNF Receptor-Associated Factor 6
|
D048029 |
[A signal transducing tumor necrosis factor receptor associated factor that is involved in regulation of NF-KAPPA B signalling and activation of JNK MITOGEN-ACTIVATED PROTEIN KINASES.
] |
|
TNF-Related Apoptosis-Inducing Ligand
|
D053221 |
[A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.
] |
|
TOR Serine-Threonine Kinases
|
D058570 |
[A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of RAPAMYCIN due to the discovery that SIROLIMUS (commonly known as rapamycin) forms an inhibitory complex with TACROLIMUS BINDING PROTEIN 1A that blocks the action of its enzymatic activity.
] |
|
TRPA1 Cation Channel
|
D000074025 |
[A highly conserved, non-selective TRP cation channel that contains 14-17 ANKYRIN REPEATS. It functions in cold sensation and NOCICEPTION of endogenous inflammatory factors and volatile irritants. TRPA1 is also activated by CANNABINOIDS and may play a role in sound perception by hair cells of the inner ear.
] |
|
TRPC Cation Channels
|
D050052 |
[A subgroup of TRP cation channels that contain 3-4 ANKYRIN REPEAT DOMAINS and a conserved C-terminal domain. Members are highly expressed in the CENTRAL NERVOUS SYSTEM. Selectivity for calcium over sodium ranges from 0.5 to 10.
] |
|
TRPC6 Cation Channel
|
D000074287 |
[A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.
] |
|
TRPM Cation Channels
|
D050053 |
[A subgroup of TRP cation channels named after melastatin protein. They have the TRP domain but lack ANKYRIN repeats. Enzyme domains in the C-terminus leads to them being called chanzymes.
] |
|
TRPP Cation Channels
|
D050396 |
[A subgroup of TRP cation channels that are widely expressed in various cell types. Defects are associated with POLYCYSTIC KIDNEY DISEASES.
] |
|
TRPV Cation Channels
|
D050916 |
[A subgroup of TRP cation channels named after the vanilloid receptor. They are very sensitive to TEMPERATURE; hot spicy food, and CAPSAICIN. They contain a TRP domain (a five-turn amphipathic helix with an invariant TRYPTOPHAN) and ANKYRIN repeats. Selectivity for CALCIUM over SODIUM ranges from 3 to 100 fold.
] |
|
TWEAK Receptor
|
D000074050 |
[A receptor for TWEAK cytokine that is highly expressed by cells in the heart, placenta, and kidney. It plays a role in ANGIOGENESIS and the proliferation of endothelial cells; it may also modulate cellular adhesion to the extracellular matrix.
] |
|
TYK2 Kinase
|
D053634 |
[A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS. The TYK2 kinase is considered the founding member of the janus kinase family and was initially discovered as a signaling partner for the INTERFERON ALPHA-BETA RECEPTOR. The kinase has since been shown to signal from several INTERLEUKIN RECEPTORS.
] |
|
Tabebuia
|
D029663 |
[A plant genus of the family BIGNONIACEAE that is a source of lapachol and beta-lapachone.
] |
|
Tabernaemontana
|
D030014 |
[A plant genus of the family APOCYNACEAE that contains bisindole alkaloids and IBOGAINE.
] |
|
Tabes Dorsalis
|
D013606 |
[Parenchymatous NEUROSYPHILIS marked by slowly progressive degeneration of the posterior columns, posterior roots, and ganglia of the spinal cord. The condition tends to present 15 to 20 years after the initial infection and is characterized by lightening-like pains in the lower extremities, URINARY INCONTINENCE; ATAXIA; severely impaired position and vibratory sense, abnormal gait (see GAIT DISORDERS, NEUROLOGIC), OPTIC ATROPHY; Argyll-Robertson pupils, hypotonia, hyperreflexia, and trophic joint degeneration (Charcot's Joint; see ARTHROPATHY, NEUROGENIC). (From Adams et al., Principles of Neurology, 6th ed, p726)
] |
|
Tables
|
D020501 |
[Presentations of data in tabular form.
] |
|
Tablets
|
D013607 |
[Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
] |
|
Tablets, Enteric-Coated
|
D013608 |
[Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
] |
|
Taboo
|
D013609 |
[Any negative tradition or behavior that is generally regarded as harmful to social welfare and forbidden within a cultural or social group.
] |
|
Tachycardia
|
D013610 |
[Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
] |
