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Paraneoplastic Cerebellar Degeneration
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D020362 |
[Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)
] |
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Paraneoplastic Endocrine Syndromes
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D009384 |
[Syndromes resulting from inappropriate production of HORMONES or hormone-like materials by NEOPLASMS in non-endocrine tissues or not by the usual ENDOCRINE GLANDS. Such hormone outputs are called ectopic hormone (HORMONES, ECTOPIC) secretion.
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Paraneoplastic Polyneuropathy
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D020364 |
[A diffuse or multifocal peripheral neuropathy related to the remote effects of a neoplasm, most often carcinoma or lymphoma. Pathologically, there are inflammatory changes in peripheral nerves. The most common clinical presentation is a symmetric distal mixed sensorimotor polyneuropathy. (Adams et al., Principles of Neurology, 6th ed, p1334)
] |
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Paraneoplastic Syndromes
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D010257 |
[In patients with neoplastic diseases a wide variety of clinical pictures which are indirect and usually remote effects produced by tumor cell metabolites or other products.
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Paraneoplastic Syndromes, Nervous System
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D020361 |
[Degenerative or inflammatory conditions affecting the central or peripheral nervous system that develop in association with a systemic neoplasm without direct invasion by tumor. They may be associated with circulating antibodies that react with the affected neural tissue. (Intern Med 1996 Dec;35(12):925-9)
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Paraneoplastic Syndromes, Ocular
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D059545 |
[Ocular manifestations secondary to various NEOPLASMS in which antibodies to antigens of the primary tumor cross-react with ocular antigens. This autoimmune response often leads to visual loss and other ocular dysfunctions.
] |
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Paranoid Behavior
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D010258 |
[Behavior exhibited by individuals who are overly suspicious, but without the constellation of symptoms characteristic of paranoid personality disorder or paranoid type of schizophrenia.
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Paranoid Disorders
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D010259 |
[Chronic mental disorders in which there has been an insidious development of a permanent and unshakeable delusional system (persecutory delusions or delusions of jealousy), accompanied by preservation of clear and orderly thinking. Emotional responses and behavior are consistent with the delusional state.
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Paranoid Personality Disorder
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D010260 |
[A personality disorder characterized by the avoidance of accepting deserved blame and an unwarranted view of others as malevolent. The latter is expressed as suspiciousness, hypersensitivity, and mistrust.
] |
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Paraoxon
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D010261 |
[An organophosphate cholinesterase inhibitor that is used as a pesticide.
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Paraparesis
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D020335 |
[Mild to moderate loss of bilateral lower extremity motor function, which may be a manifestation of SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; MUSCULAR DISEASES; INTRACRANIAL HYPERTENSION; parasagittal brain lesions; and other conditions.
] |
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Paraparesis, Spastic
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D020336 |
[Mild or moderate loss of motor function accompanied by spasticity in the lower extremities. This condition is a manifestation of CENTRAL NERVOUS SYSTEM DISEASES that cause injury to the motor cortex or descending motor pathways.
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Paraparesis, Tropical Spastic
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D015493 |
[A subacute paralytic myeloneuropathy occurring endemically in tropical areas such as the Caribbean, Colombia, India, and Africa, as well as in the southwestern region of Japan; associated with infection by HUMAN T-CELL LEUKEMIA VIRUS I. Clinical manifestations include a slowly progressive spastic weakness of the legs, increased reflexes, Babinski signs, incontinence, and loss of vibratory and position sensation. On pathologic examination inflammatory, demyelination, and necrotic lesions may be found in the spinal cord. (Adams et al., Principles of Neurology, 6th ed, p1239)
] |
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Parapharyngeal Space
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D000080886 |
[The deep neck space near the PHARYNX located anterior to the ptyergomandibular raphe, posterior to the prevertebral fascia, inferior to the SKULL BASE, and superior to the HYOID BONE. Prestyloid parapharyngeal space contains cranial nerves IX, X, XI, XII and internal JUGULAR VEIN and internal CAROTID ARTERY. Poststyloid parapharyngeal space contains AURICULARTEMPORAL NERVE and MAXILLARY ARTERY and ascending pharyngeal artery.
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Paraphilic Disorders
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D010262 |
[Disorders that include recurrent, intense sexually arousing fantasies, sexual urges, or behaviors generally involving nonhuman objects, suffering of oneself or partners, or children or other nonconsenting partners. (from DSM-V)
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Paraphimosis
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D010263 |
[A condition in which the FORESKIN, once retracted, cannot return to its original position. If this condition persists, it can lead to painful constriction of GLANS PENIS, swelling, and impaired blood flow to the penis.
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Paraplegia
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D010264 |
[Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
] |
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Parapoxvirus
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D018157 |
[A genus of the family POXVIRIDAE, subfamily CHORDOPOXVIRINAE, which infect ungulates and may infect humans. ORF VIRUS is the type species.
] |
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Paraproteinemias
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D010265 |
[A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.
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Paraproteins
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D010266 |
[Abnormal immunoglobulins synthesized by atypical cells of the MONONUCLEAR PHAGOCYTE SYSTEM. Paraproteins containing only light chains lead to Bence Jones paraproteinemia, while the presence of only atypical heavy chains leads to heavy chain disease. Most of the paraproteins show themselves as an M-component (monoclonal gammopathy) in electrophoresis. Diclonal and polyclonal paraproteins are much less frequently encountered.
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