Any of various diseases affecting the white matter of the central nervous system.

Synonyms: CACH VWM Syndromes, Childhood Ataxia with Diffuse Central Nervous System Hypomyelination, Syndrome, CACH VWM, VWM Syndrome, CACH, Leukoencephalopathies, Vanishing White Matter Disease, Childhood Ataxia with Central Nervous System Hypomyelination, White Matter Diseases, Leukoencephalopathy, Childhood Ataxia with Central Nervous System Hypomyelinization, Diffusas, Myelinosis Centralis, Myelinosis Centralis Diffusa, Vanishing White Matter Leukodystrophy, Leukoencephalopathy with Vanishing White Matter, Cree Leukoencephalopathy, CACH VWM Syndrome, Diffusa, Myelinosis Centralis, Myelinosis Centralis Diffusas, CACH Syndrome, CACH Syndromes, Leukoencephalopathy, Cree, Cree Leukoencephalopathies, White Matter Disease, Centralis Diffusa, Myelinosis