A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.

Synonyms: Cyclic Nucleotide Phosphodiesterases, Type 1, Calcium-Calmodulin-Dependent Phosphodiesterase, Phosphodiesterase 1C, Calmodulin-Dependent, Cyclic Nucleotide Phosphodiesterase PDE1 Family, PDE1 Phosphodiesterases, Calcium Calmodulin Stimulated Cyclic AMP Phosphodiesterase, Phosphodiesterases, PDE1, Calcium-Calmodulin-Stimulated Cyclic AMP Phosphodiesterase, Calmodulin-Dependent cGMP Phosphodiesterase, Calmodulin Dependent cGMP Phosphodiesterase, Phosphodiesterase 1B, Calmodulin-Dependent, Phosphodiesterase 1A, Calmodulin Dependent, Calmodulin-Dependent Phosphodiesterase, Ca-CaM-Phosphodiesterase, Calmodulin Phosphodiesterase, Phosphodiesterase 1C, Calmodulin Dependent, cGMP Phosphodiesterase, Calmodulin-Dependent, Cyclic Nucleotide Phosphodiesterases, Type 1C, Cyclic Nucleotide Phosphodiesterases, Type 1B, Cyclic Nucleotide Phosphodiesterases, Type 1A, Cyclic Nucleotide Phosphodiesterases, Type I, Calmodulin Dependent Phosphodiesterase, Phosphodiesterase 1B, Calmodulin Dependent, Calmodulin-Dependent Phosphodiesterase 1B, Calmodulin-Dependent Phosphodiesterase 1A, Ca CaM Phosphodiesterase, Ca(2+)-CaM-Stimulated PDE, Phosphodiesterase 1A, Calmodulin-Dependent, Calmodulin-Dependent Phosphodiesterase 1C, Phosphodiesterase, Calcium-Calmodulin-Dependent, EC 3.1.4.17, Ca++ Calmodulin Dependent Cyclic AMP Phosphodiesterase, Calcium Calmodulin Dependent Phosphodiesterase, Phosphodiesterase, Calmodulin-Dependent cGMP