An autosomal dominant hereditary skin disease characterized by epidermolytic hyperkeratosis that is strictly confined to the palms and soles. It has been associated with mutations in the gene that codes for KERATIN-9.

Synonyms: Palmoplantar Keratoderma, Epidermolytic, Keratodermas, Epidermolytic Palmoplantar, Epidermolytic Hyperkeratosis, Localized, EPPK (Epidermolytic Palmoplantar Keratoderma), Epidermolytic Unna-Thost Disease, Keratoderma, Palmoplantar, Epidermolytic, Localized Epidermolytic Hyperkeratosis, Palmoplantar Keratodermas, Epidermolytic, Keratoderma, Epidermolytic Palmoplantar, Localized Epidermolytic Hyperkeratoses, Hyperkeratosis, Localized Epidermolytic, Hyperkeratoses, Localized Epidermolytic, Thost-Unna Disease, Epidermolytic, Greither Keratosis, Epidermolytic Palmoplantar Keratoderma, EPPKs (Epidermolytic Palmoplantar Keratoderma), Epidermolytic Hyperkeratoses, Localized, Unna Thost Disease, Epidermolytic, Epidermolytic Palmoplantar Keratoderma Vorner Type, Thost Unna Disease, Epidermolytic, Unna-Thost Disease, Epidermolytic, Epidermolytic Palmoplantar Keratodermas, Epidermolytic Thost-Unna Disease, Keratosis of Greither