The process of generating thrombocytes (BLOOD PLATELETS) from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via the MEGAKARYOCYTES. The humoral factor with thrombopoiesis-stimulating activity is designated THROMBOPOIETIN.

A complex process that involves the proliferation of MEGAKARYOCYTES in BONE MARROW, their differentiation in size and ploidy, and maturation before the release of functional BLOOD PLATELETS.

Synonyms: Megakaryocytopoiesis, Thrombocytopoieses, Thrombopoiesis, Megakaryocytopoieses, Thrombocytopoiesis, Thrombopoieses