A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
Synonyms: 0, MK 733, Synvinolin, MK-733, Simvastatin, MK733, Zocor, AGG2FN16EV
Instance information
comment
98; SIMVASTATIN was indexed under LOVASTATIN/analogs & derivatives 1988-97 & NAPHTHALENES 1986-87 ,98; use SIMVASTATIN (NM) 1986-97
identifier
D019821