A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
Synonyms: Proto-Oncogene Protein kit, kit Proto Oncogene Protein, p145 c-kit, Proto-Oncogene Protein c-kit, c-kit Receptor, EC 2.7.10.1, Proto Oncogene Protein kit, c-kit, p145, Receptor, Stem Cell Factor, Proto Oncogene Proteins c kit, c-kit, Proto-Oncogene Proteins, p145(c-kit), p145c kit, CD117 Antigens, c kit Protein, Proto-Oncogene Protein, kit, Antigens, CD117, p145c-kit, CD117 Antigen, Proto Oncogene Protein c kit, Proto-Oncogene Proteins c-kit, Stem Cell Factor Receptor, c kit Receptor, c-kit, Proto-Oncogene Protein, kit Proto-Oncogene Protein, SCF Receptor, p145 c kit, c-kit Protein
Instance information
2000; see PROTO-ONCOGENE PROTEINS C-KIT 1999-1996; PROTO-ONCOGENE PROTEIN KIT (now PROTO-ONCOGENE PROTEIN C-KIT) was indexed under RECEPTOR PROTEIN-TYROSINE KINASE 1994-1995; RECEPTORS, COLONY-STIMULATING FACTOR 1991-1995; & PROTO-ONCOGENE PROTEINS 1989-1995 ,2000(1996); use PROTO-ONCOGENE PROTEIN c-KIT (NM) 1989-1995
D019009