A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.

Synonyms: HIVID Roche, 2',3' Dideoxycytidine, Zalcitabine, NSC-606170, 2',3'-Dideoxycytidine, NSC606170, 6L3XT8CB3I, 0, Dideoxycytidine, Hivid, NSC 606170, ddC (Antiviral), Cytidine, 2',3'-dideoxy-

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94; was DIDEOXYCYTIDINE 1990-93 ,use ZALCITABINE to search DIDEOXYCYTIDINE 1990-93

identifier

D016047

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