A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.
Synonyms: Preprorenin, EC 3.4.23.15, Angiotensin-Forming Enzyme, Renin, Inactive, Angiotensin Forming Enzyme, Renin, Big, Big Renin, Angiotensinogenase, Renin, EC 3.4.23.-, Pre Prorenin, Prorenin, Inactive Renin, Cryorenin, Pre-Prorenin
Instance information
do not confuse with RENNIN see CHYMOSIN ,1963; PRORENIN was listed under ENZYME PRECUSORS & RENIN 1977-2003; PREPRORENIN was listed under ENZYME PRECUSORS & RENIN 1980-2003 ,1963; for PRORENIN use RENIN (NM) 1977-2003, for PREPRORENIN use RENIN (NM) 1980-2003
D012083