Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component of the central nervous system. Damage to optic nerve fibers may occur at or near their origin in the retina, at the optic disk, or in the nerve, optic chiasm, optic tract, or lateral geniculate nuclei. Clinical manifestations may include decreased visual acuity and contrast sensitivity, impaired color vision, and an afferent pupillary defect.

Synonyms: Foster Kennedy Syndrome, Optic Nerve Diseases, Optic Disk Disorders, Neuropathy, Optic, Optic Neuropathies, Neural-Optical Lesion, Cranial Nerve II Disorder, Neural Optical Lesion, Disorder, Optic Disc, Optic Nerve Disease, Optic Disk Disorder, Cranial Nerve II Diseases, Disc Disorder, Optic, Neural-Optical Lesions, Optic Neuropathy, Optic Disc Disorder, Disk Disorder, Optic, Syndrome, Foster-Kennedy, Optic Disc Disorders, Second Cranial Nerve Diseases, Foster-Kennedy Syndrome, Lesion, Neural-Optical