Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.

Synonyms: Factor I, Coagulation, 0, gamma-Fibrinogen, 9001-32-5, gamma Fibrinogen, Fibrinogen, Blood Coagulation Factor I, Coagulation Factor I, Fibrinogens, Factor I