A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
Synonyms: Hydrochloride, Buprenorphine, Temgésic, 6029-M, Temgesic, 6029M, RX-6029-M, Buprenex, Buprex, 56W8MW3EN1, 6029 M, 0, Prefin, 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (5alpha,7alpha(S))-, Buprenorphine, RX 6029 M, 40D3SCR4GZ, Subutex, Buprenorphine Hydrochloride, RX6029M
Instance information
for buprenorphine maintenance treatment, coordinate with OPIATE SUBSTITUTION TREATMENT ,87; was see under MORPHINANS 1979-86 ,87(79); was see under MORPHINANS 1979-86
D002047