Monooxygenases that oxidize exogenous substrates.

A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.

Synonyms: EC 1.14.14.1, Monooxygenases, Xenobiotic, Monooxygenases, Microsomal, Microsomal Monooxygenases, Hydroxylases, Aryl Hydrocarbon, Xenobiotic Monooxygenases, Aryl Hydrocarbon Hydroxylases