Intracellular signaling proteins that are defined by the presence of a NUCLEOTIDE-binding region and LEUCINE-rich repeats. Their general structure consists of any of a variety of effector domains at their N-termini such as a caspase recruitment domain (CARD), a central nucleotide-binding domain, and a variable number of C-terminal leucine-rich repeats. They are important for pathogen recognition in the INNATE IMMUNE RESPONSE of animals and plants. Members of the NLR protein family include the NOD SIGNALING ADAPTOR PROTEINS.

Synonyms: Nucleotide binding Domain Leucine rich Repeat Proteins, NLR Proteins, Nucleotide-Binding Domain Leucine-Rich Repeat Protein, NOD like Receptors, NLR Protein, NOD-like Receptor, Proteins, NLR, 0, NOD-like Receptors, Protein, NLR, Receptor, NOD-like, NOD like Receptor, Nucleotide-binding Domain Leucine-rich Repeat Proteins, Receptors, NOD-like, Nucleotide Binding Domain Leucine Rich Repeat Protein